Myocardial Infarction Research

Myocardial infarction (MI) - more commonly referred to as a heart attack - is an acute event caused by the interruption of blood supply to regions of the heart, leading to myocardial necrosis. Infarction of a substantial area of the myocardium can disrupt normal conductance of the heart, leading to cardiac arrest.In the majority of cases, an MI is immediately preceded by the presence of an occlusive thrombus within a coronary artery, blocking blood flow to the downstream tissue. The most common cause of an occlusive thrombus within a coronary artery is the rupture of an atherosclerotic plaque. However, the occlusion of a coronary artery may also result from coronary embolism. This can occur in patients following stent placement, angioplasty, and coronary artery bypass grafting.

Myocardial Infarction Research Products Targets

Products for Myocardial Infarction Research - Page 36

Cat.No. Product Name Information/Activity
BCC7080 (-)-[3R,4S]-Chromanol 293B 163163-24-4
BCC7048 CP 339818 hydrochloride 478341-55-8
BCC3770 Dofetilide Dofetilide(Tikosyn) is a class III antiarrhythmic agent.
BCC7398 DPO-1 43077-30-1
BCC7182 E-4031 dihydrochloride E-4031 is a class III antiarrhythmic agent which selectively blocks hERG potassium channel.
BCC7806 JNJ 303 JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3 μM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).
BCC1682 KN-92 phosphate KN-92 phosphate is an inactive derivative of KN-93.
BCC1683 KN-93 CaM kinase II inhibitor; also K+ channel blocker (KV),KN-93 is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II, with Ki of 370 nM.
BCC7231 Linopirdine dihydrochloride 113168-57-3
BCC7709 Margatoxin Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research.