Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 25

  1. Cat.No. Product Name Information/Activity
  2. BCC7025 Nafadotride 149649-22-9 Nafadotride chemical structure
  3. BCC7435 NGB 2904 189061-11-8 NGB 2904 chemical structure
  4. BCC7801 PG 01037 dihydrochloride 675599-62-9 PG 01037 dihydrochloride chemical structure
  5. BCC7664 PNU 177864 hydrochloride 250266-51-4 PNU 177864 hydrochloride chemical structure
  6. BCC7887 SB 277011A dihydrochloride SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively. SB 277011A dihydrochloride chemical structure
  7. BCC7029 U 99194 maleate 234757-41-6 U 99194 maleate chemical structure
  8. BCC6224 A 412997 dihydrochloride Selective D<sub>4</sub> agonist A 412997 dihydrochloride chemical structure
  9. BCC7293 ABT 724 trihydrochloride ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile. ABT 724 trihydrochloride chemical structure
  10. BCC6919 PD 168077 maleate PD-168077 maleate is a selective dopamine D4 receptor agonist, with a Ki of 9 nM. PD 168077 maleate chemical structure
  11. BCC7330 Ro 10-5824 dihydrochloride Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM. Ro 10-5824 dihydrochloride chemical structure

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