Neural Development
Neural development describes the growth and development of the nervous system starting from embryogenesis and continuing throughout life.
Neural Development Products Targets
- FGFR (5)
- GABAB Receptor (28)
- Others (13)
- Stem Cell Signaling (27)
- Stem Cell Proliferation (25)
- Reprogramming (17)
- Nucleoside Transporter (5)
- Glycine Transporter (6)
- GABA (10)
- Cannabinoid Transporter (10)
- Acetylcholine Transporter (1)
- D4 Receptor (12)
- PORCN (4)
- beta-catenin (13)
- Casein Kinase 1 (7)
- 5-HT7 Receptor (11)
- 5-HT6 Receptor (14)
- 5-ht5 Receptor (2)
- 5-HT4 Receptor (17)
- NOP Receptor (21)
- Mu-Opioid Receptors (15)
- Kappa Opioid Receptors (14)
- AMPA Receptor (45)
- GABAA-ρ Receptor (8)
- GABAA Receptor (66)
- GPR55 (8)
- CB2 Receptor (6)
- CB1 Receptor (17)
- Nicotinic (α7) Receptor (25)
- Nicotinic (α4β2) Receptor (14)
- D3 Receptor (12)
- Vesicular Monoamine Transporter (4)
- NMDA Receptor (87)
- Kainate Receptor (22)
- D2 Receptor (14)
- D1 and D5 Receptor (16)
- Glutamate Transporter (18)
- Dopamine Transporter (20)
- Tankyrase (5)
- Adrenergic Transporter (23)
- 5-HT Transporter (30)
- nNOS (5)
- iNOS (11)
- eNOS (1)
- Stem Cell Differentiation (54)
- Delta opioid receptor (16)
- Adrenergic α2 Receptor (33)
- Adrenergic α1 Receptor (22)
- Adrenergic β3 Receptor (12)
- Adrenergic β2 Receptor (6)
- Adrenergic β1 Receptor (7)
- Hedgehog Signaling (15)
- Cancer Stem Cell (9)
Products for Neural Development - Page 69
- Cat.No. Product Name Information/Activity
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BCN2207
Ascorbic acid
PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02. PROTAC EED degrader-1 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8.17) targeting the EED subunit.
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BCC1130
5-Azacytidine
5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy.
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BCC3918
(±)-Bay K 8644
Ca<sup>2+</sup> channel activator (L-type); aids generation of iPSCs from MEFs
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BCC1275
CHIR-99021 (CT99021)
CHIR-99021 (CT99021) is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 induces autophagy.
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BCC7047
Kenpaullone
Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively.
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BCC7738
Neurodazine
Neurodazine is an imidazole-based small molecule, serve as a promoter of neurogenesisin pluripotent cells. Neurodazine promotes neurogenesis by activating Wnt and Shh signaling pathways. Neurodazine selectively suppresses astrocyte differentiation of P19 cells.
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BCC6542
O4I1
O4I1 is as a potent Oct3/4 inducer.
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BCC1277
PD0325901
PD0325901 is a selective and cell permeable MEK inhibitor with an IC50 of 0.33 nM.
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BCC2412
Pifithrin-μ
Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.
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BCC1887
RepSox
RepSox is a potent and selective of the TGFβR-1/ALK5 inhibitor which inhibits ALK5 autophosphorylation with IC50 of 4 nM.
