Nociception

Nociception is the sensory process that provides the signals that lead to pain. This occurs through nociceptors, primary sensory neurons that are activated by stimuli that cause tissue damage. Stimuli can include tissue injury, extremes of heat and noxious chemicals. Unlike other sensory neurons that detect vision or taste, nociceptors are located all around the body, particularly under the skin, however, they are notably absent from the brain.

Nociception Products Targets

Products for Nociception - Page 31

Cat.No. Product Name Information/Activity
BCC7282 L-755,507 L755507 is a potent, selective agonist of β3-AR with an IC50 of 35 nM.
BCC6881 Pindolol Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM).
BCC7833 SR 58611A hydrochloride Amibegron hydrochloride is a selective β3-adrenoceptor agonist, with an EC50 of 3.5 nM for β-adrenoceptor in rat colon; Amibegron hydrochloride has anxiolytic and antidepressant activity.
BCC5878 ZD 2079 178600-17-4
BCC6852 ZD 7114 hydrochloride 129689-28-7
BCC7475 L-748,337 244192-94-7
BCC7094 SR 59230A hydrochloride SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.
BCC7026 Arvanil 128007-31-8
BCC5756 Noladin ether 222723-55-9
BCC6827 Oleamide Oleamide is an endogenous fatty acid amide which can be synthesized de novo in the mammalian nervous system, and has been detected in human plasma.