Sleep Research

Sleep is characterized by altered consciousness, it is split into two distinct stages- rapid eye movement (REM) and non-REM. The circadian clock controls the pattern of sleep and wakefulness. It is regulated by the light levels, temperature, metabolites, neurotransmitters, neuropeptides, and neurohormones, which cause a daily fluctuation in expression levels of many sleep-related genes.

Sleep Research Products Targets

Products for Sleep Research - Page 14

Cat.No. Product Name Information/Activity
BCC6101 JNJ 5207852 dihydrochloride JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.
BCC7245 ROS 234 dioxalate 184576-87-2
BCC6182 SEN 12333 874450-44-9
BCC6734 Thioperamide 106243-16-7
BCC7383 VUF 5681 dihydrobromide 639089-06-8
BCC6651 6-Chloromelatonin 63762-74-3
BCC6772 2-Iodomelatonin 2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.
BCN2196 Melatonin Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation.
BCC6901 8-M-PDOT 8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity.
BCC6748 2-Phenylmelatonin 151889-03-1