Sleep Research
Sleep is characterized by altered consciousness, it is split into two distinct stages- rapid eye movement (REM) and non-REM. The circadian clock controls the pattern of sleep and wakefulness. It is regulated by the light levels, temperature, metabolites, neurotransmitters, neuropeptides, and neurohormones, which cause a daily fluctuation in expression levels of many sleep-related genes.
Sleep Research Products Targets
- Adenosine A2A Receptor (11)
- GABAB Receptor (28)
- 5-HT2C Receptor (23)
- 5-HT2B Receptor (12)
- 5-HT2A Receptor (25)
- Melatonin Receptor (10)
- GABAA-ρ Receptor (8)
- GABAA Receptor (66)
- Retinoic Acid-related Orphan Receptor (4)
- Rev-Erb Receptor (2)
- DREADD Ligands (1)
- D3 Receptor (12)
- 5-HT3 Receptor (39)
- D2 Receptor (14)
- Histamine H3 Receptor (22)
- Adenosine A1 Receptor (12)
- OX2 Receptor (4)
- OX1 Receptor (5)
Products for Sleep Research - Page 10
- Cat.No. Product Name Information/Activity
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BCC6988
CGP 35348
Brain penetrant, selective GABA<sub>B</sub> antagonist
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BCC7605
CGP 36216 hydrochloride
GABA<sub>B</sub> antagonist; displays activity at presynaptic receptors
-
BCC6990
CGP 46381
123691-14-5
-
BCC6989
CGP 52432
CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM.
-
BCC6934
CGP 54626 hydrochloride
149184-21-4
-
BCC5737
CGP 55845 hydrochloride
Potent, selective GABA<sub>B</sub> antagonist
-
BCC6579
2-Hydroxysaclofen
117354-64-0
-
BCC6562
Phaclofen
114012-12-3
-
BCC6580
Saclofen
125464-42-8
-
BCC5692
SCH 50911
SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM.
