Sleep Research

Sleep is characterized by altered consciousness, it is split into two distinct stages- rapid eye movement (REM) and non-REM. The circadian clock controls the pattern of sleep and wakefulness. It is regulated by the light levels, temperature, metabolites, neurotransmitters, neuropeptides, and neurohormones, which cause a daily fluctuation in expression levels of many sleep-related genes.

Sleep Research Products Targets

Products for Sleep Research - Page 5

Cat.No. Product Name Information/Activity
BCC7160 N6-Cyclopentyladenosine N6-Cyclopentyladenosine (CPA) is a selective Adenosine A1 receptor agonist, with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively.
BCC7716 (±)-5'-Chloro-5'-deoxy-ENBA Highly selective A<sub>1</sub> agonist
BCC7215 GR 79236 GR79236 is a highly potent and selective adenosine A1 receptor agonist (Ki = 3.1 nM) that has analgesic and anti-inflammatory actions in humans and animals.
BCC7311 2'-MeCCPA 205171-12-6
BCC7374 SDZ WAG 994 130714-47-5
BCC6664 1,3-Dipropyl-8-phenylxanthine 85872-53-3
BCC6649 DPCPX 102146-07-6
BCC6124 KW 3902 Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450). Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases.
BCC7240 PSB 36 524944-72-7
BCC7656 SLV 320 Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats.