Sleep Research
Sleep is characterized by altered consciousness, it is split into two distinct stages- rapid eye movement (REM) and non-REM. The circadian clock controls the pattern of sleep and wakefulness. It is regulated by the light levels, temperature, metabolites, neurotransmitters, neuropeptides, and neurohormones, which cause a daily fluctuation in expression levels of many sleep-related genes.
Sleep Research Products Targets
- Adenosine A2A Receptor (11)
- GABAB Receptor (28)
- 5-HT2C Receptor (23)
- 5-HT2B Receptor (12)
- 5-HT2A Receptor (25)
- Melatonin Receptor (10)
- GABAA-ρ Receptor (8)
- GABAA Receptor (66)
- Retinoic Acid-related Orphan Receptor (4)
- Rev-Erb Receptor (2)
- DREADD Ligands (1)
- D3 Receptor (12)
- 5-HT3 Receptor (39)
- D2 Receptor (14)
- Histamine H3 Receptor (22)
- Adenosine A1 Receptor (12)
- OX2 Receptor (4)
- OX1 Receptor (5)
Products for Sleep Research - Page 12
- Cat.No. Product Name Information/Activity
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BCC6230
Phenobarbital sodium salt
57-30-7
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BCC2156
Valproic acid sodium salt (Sodium valproate)
Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
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BCC2512
Zonisamide
Zonisamide is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.
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BCC4530
Histamine 2HCl
Histamine dihydrochloride is an endogenous metabolite.
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BCC6768
Imetit dihydrobromide
Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM).
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BCC6853
Immepip dihydrobromide
164391-47-3
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BCC7524
Methimepip dihydrobromide
817636-54-7
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BCC5665
(R)-(-)-α-Methylhistamine dihydrobromide
(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histamine receptor agonist with a Kd of 50.3 nM. (R)-(-)-α-Methylhistamine dihydrobromide can cross the blood-brain barrier, and can enhance memory retention, attenuates memory impairment in rats.
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BCC6700
(S)-(+)-α-Methylhistamine dihydrobromide
75614-93-6
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BCC6701
Nα-Methylhistamine dihydrochloride
16503-22-3
