Protein Ser/Thr Phosphatases
Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.
Products for Protein Ser/Thr Phosphatases
- Cat.No. Product Name Information
- BCC2456 Calcineurin Autoinhibitory PeptideSelective calcineurin inhibitor
- BCC2457 Calyculin AProtein phosphatase 1 and 2A inhibitor
- BCC2458 CeramideSer/Thr protein phosphatase activator
- BCC2459 DL-AP3Phosphoserine phosphatase inhibitor
- BCC2460 Fostriecin sodium saltPotent PP2A and PP4 inhibitor
- BCC2461 Fumonisin B1Inhibitor of Ser/Thr phosphatase. Also inhibits sphingosine N-acyltransferase
- BCC2462 INCA-6Inhibitor of calcineurin-substrate association
- BCC2463 NFAT InhibitorInhibitor of calcineurin-mediated NFAT activation
- BCC2464 Okadaic acidProtein phosphatase 1 and 2A inhibitor
- BCC2465 Sal 003Cellular phosphatase complex inhibitor
- BCC2466 Alexidine dihydrochlorideSelective inhibitor of PTPMT1; maintains functional HSCs ex vivo
- BCC2467 BVT 948Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling
- BCC2468 NSC 87877Potent inhibitor of shp2 and shp1 PTP
- BCC2469 TCS 401Selective PTP1B inhibitor
- BCC3636 CID 2011756Pan protein kinase D (PKD) inhibitor; cell permeable
- BCC3980 Sephin1Selective PPP1R15A inhibitor
- BCC4187 Nafamostat
- BCC4188 Nafamostat hydrochloride
- BCC5147 CCT007093PPM1D inhibitor
- BCC5506 PTP1B-IN-1
- BCC5532 LB-100
- BCC6481 Sanguinarine chlorideInhibitor of protein phosphatase 2C (PP2C)
- BCC7109 NSC 95397Selective Cdc25 dual specificity phosphatase inhibitor
- BCC7199 NSC 663284Cdc25 phosphatase inhibitor; blocks cdk1 and cdk2 activation
- BCC7320 TautomycetinSelective PP1 inhibitor