Thrombin

Thrombin is a Na+ -activated allosteric serine protease that catalyzes the formation of thrombus as well as a series of flux-regulating reactions through the coagulation cascade. In response to vascular injury, thrombin is produced through the activation of its inactive precursor, prothrobin, catalyzed by Factor Xa (a trypsin-like proteinase). As a serine protease characterized by the presence of a catalytic triad, thrombin possess a triad of S195-H57-D189 in its active center, which is required for the nucleophilic attack of the target peptide bond. Located “south-west” of the active center is a Na+ -binding site, through which the binding of a sodium ion allosterically modulates the activity of the serine proteinase.

Products for Thrombin

  1. Cat.No. Product Name Information
  2. BCC1313 5-R-RivaroxabanFactor Xa (FXa) inhibitor
  3. BCC1421 Bivalirudin TrifluoroacetateReversible thrombin inhibitor
  4. BCC1511 Dabigatran etexilate mesylateDirect thrombin inhibitor,anticoagulant,prodrug of dabigatran
  5. BCC1512 Dabigatran ethyl esterThrombin activity inhibitor
  6. BCC1543 EdoxabanFactor Xa inhibitor
  7. BCC1544 Edoxaban tosylateFxa inhibitor
  8. BCC1545 Edoxaban tosylate monohydrateOral factor Xa inhibitor
  9. BCC1827 OtamixabanDirect factor Xa inhibitors,potent and selective
  10. BCC2139 BIBR 953 (Dabigatran, Pradaxa)Thrombin inhibitor,potent,reversible and direct
  11. BCC2295 ApixabanFactor Xa inhibitor
  12. BCC3738 BIBR-1048Thrombin inhibitor
  13. BCC6382 Ximelagatranthrombin inhibitor,orally available

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