Thrombin
Thrombin is a Na+ -activated allosteric serine protease that catalyzes the formation of thrombus as well as a series of flux-regulating reactions through the coagulation cascade. In response to vascular injury, thrombin is produced through the activation of its inactive precursor, prothrobin, catalyzed by Factor Xa (a trypsin-like proteinase). As a serine protease characterized by the presence of a catalytic triad, thrombin possess a triad of S195-H57-D189 in its active center, which is required for the nucleophilic attack of the target peptide bond. Located “south-west” of the active center is a Na+ -binding site, through which the binding of a sodium ion allosterically modulates the activity of the serine proteinase.
Products for Thrombin
- Cat.No. Product Name Information
- BCC1313 5-R-RivaroxabanFactor Xa (FXa) inhibitor
- BCC1421 Bivalirudin TrifluoroacetateReversible thrombin inhibitor
- BCC1511 Dabigatran etexilate mesylateDirect thrombin inhibitor,anticoagulant,prodrug of dabigatran
- BCC1512 Dabigatran ethyl esterThrombin activity inhibitor
- BCC1543 EdoxabanFactor Xa inhibitor
- BCC1544 Edoxaban tosylateFxa inhibitor
- BCC1545 Edoxaban tosylate monohydrateOral factor Xa inhibitor
- BCC1827 OtamixabanDirect factor Xa inhibitors,potent and selective
- BCC2139 BIBR 953 (Dabigatran, Pradaxa)Thrombin inhibitor,potent,reversible and direct
- BCC2295 ApixabanFactor Xa inhibitor
- BCC3738 BIBR-1048Thrombin inhibitor
- BCC6382 Ximelagatranthrombin inhibitor,orally available