Natural Products from Tripterygium wilfordii
Natural Products Isolated from Tripterygium wilfordii
BioCrick provides high-purity natural products and bioactive compounds isolated and purified from natural sources for scientific research.
- Natural product compounds selected from diverse chemical and biological sources.
- Broad structural diversity and coverage of biological activities.
- Product activity information can be supported by published literature, patents and research reports.
- Natural products can be selected according to source, target, activity and disease research interests.
- Compounds should be stored according to the product specifications after receipt.
Natural Products from Tripterygium wilfordii
23 natural product s associated with Tripterygium wilfordii
| Catalog No. | Product Name | CAS Number | COA |
|---|---|---|---|
| BCN4519 |
(-)-Epigallocatechin(EGC)
|
970-74-1 | COA |
| BCN6214 |
3,4-Dihydroxybenzaldehyde
|
139-85-5 | COA |
| BCN5986 |
Celastrol
|
34157-83-0 | COA |
| BCN2282 |
Demethylzeylasteral
|
107316-88-1 | COA |
| BCC8980 |
Euojaponine D
|
128397-42-2 | COA |
| BCN3087 |
Evonine
|
33458-82-1 | COA |
| BCC8998 |
Hyponine D
|
259823-31-9 | COA |
| BCC8999 |
Hyponine E
|
226975-99-1 | COA |
| BCN5616 |
Oleanolic acid
|
508-02-1 | COA |
| BCC9117 |
Peritassine A
|
262601-67-2 | COA |
| BCN6315 |
Procyanidin B2
|
29106-49-8 | COA |
| BCN5890 |
Succinic acid
|
110-15-6 | COA |
| BCN5984 |
Triptolide
|
38748-32-2 | COA |
| BCN5924 |
Triptonide
|
38647-11-9 | COA |
| BCN3095 |
Triptonine B
|
168009-85-6 | COA |
| BCN2546 |
Triptophenolide
|
74285-86-2 | COA |
| BCN4327 |
Ursolic acid
|
77-52-1 | COA |
| BCN3083 |
Wilfordine
|
37239-51-3 | COA |
| BCN5427 |
Wilforgine
|
37239-47-7 | COA |
| BCN5994 |
Wilforine
|
11088-09-8 | COA |
| BCN4383 |
Wilforlide A
|
84104-71-2 | COA |
| BCN3099 |
Wilfornine A
|
345954-00-9 | COA |
| BCN3085 |
Wilfortrine
|
37239-48-8 | COA |
References
Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug.[Pubmed: 30112986]
Triptolide, a bioactive component in Tripterygium wilfordii extracts, possess strong anti-proliferative activity on all 60-national cancer institute (NCI) cancer cell lines. The antitumor property of triptolide has made it become a promising anti-cancer drug. However, the widespread use of triptolide in the clinical practice is greatly limited for its multi-organ toxicity and narrow therapeutic window. All the toxic characteristics of triptolide are associated with the pharmacokinetics especially its distribution and accumulation in the target organ. The article presents a comprehensive review of the preclinical pharmacokinetics of triptolide. Oral triptolide is rapidly and highly absorbed. Grapefruit juice affects oral absorption, increasing the area under the concentration-time curve (AUC) by 153 % and the maximum concentration (Cmax) by 141 %. The AUC and the Cmax are not dose proportional. Triptolide distributes into the liver, heart, spleen, lung and kidney. Biotransformation of triptolide in rats includes hydroxylation, sulfate, glucuronide, N-acetylcysteine (NAC) and glutathione (GSH) conjugation and combinations of these pathways. Less than 4 % of triptolide was recovered from the feces, bile and urine within 24 h. After repeating dosage, triptolide was eliminated quickly without accumulation in vivo. As a substrate of P-glycoprotein (P-gp) and CYP3A4, triptolide could have clinically significant pharmacokinetic interactions with those proteins substrates/inhibitors.
[Chemical Constituents of An Endophytic Fungus from Tripterygium wilfordii and Their Monoamine Oxidase Inhibitory Activity}[Pubmed: 30088877]
To study the chemical constituents and monoamine oxidase inhibitory activity of Talaromyces wortmannii,an endophytic fungus was isolated from Tripterygium wilfordii.