Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN3877 | Alpha-caryophyllene |
| Alpha-humulene and trans-caryophyllene extracted from S.officinalis essential oil can inhibit tumor cell growth; they also show marked anti-inflammatory effects, probably by interfering with TNFalpha production. | |
| BCN3880 | alpha-Carotene |
| 1. alpha-Carotene has a stronger effect than beta-carotene in suppressing the promoting activity of 12-O-tetradecanoylphorbol-13-acetate on skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated mice. 2. alpha-Carotene has inhibitory effects on proliferation of the human neuroblastoma cell line GOTO. 3. alpha-Carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice. | |
| BCN3884 | Brevifolincarboxylic acid |
| 1. Brevifolincarboxylic acid shows marked inhibitory effects on aryl hydrocarbon receptor -based bioassay activation by TCDD, and its effect is dose dependent. 2. Brevifolincarboxylic acid (IC50 = 18.0 uM) shows good antioxidant activity. 3. Brevifolincarboxylic acid shows moderate antibacterial activity against Salmonella enteritidis , Salmonella typhimurium , and Salmonella abony. | |
| BCN3886 | Gitogenin |
| 1. Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. 2. Gitogenin and (25S)-5α-furastan-3β,22,26-triol are the inhibitors of enzyme α-glucosidase with IC50 values of 37.2±0.18 and 33.5±0.22 uM, respectively. 3. Gitogenin shows moderate stimulation of release activity on growth hormone from rat pituitary cells. | |
| BCN3888 | Soybean phospholipid |
| Soybean phospholipid has a growth-promoting effect and it is suitable as a lipid and phospholipid source in microdiets for P. fulvidraco larvae feed.Soybean phospholipid and safflower phospholipid can suppress the elevation of plasma and liver cholesterol and that this effect may be brought about by inhibiting the absorption of cholesterol in the small intestine. | |
| BCN6697 | Vitisin B |
| 1. Vitisin B can stimulate osteoblastogenesis via estrogen receptor-mediated pathway. 2. (-)-Vitisin B can significantly inhibit cell proliferation through inducing cell apoptosis in human HL-60 promyelocytic leukemia cells, it induces apoptosis of leukemia cells might be mediated through activation of JNK and Fas death-signal transduction. 3. Vitisin B can inhibits migration through inhibition of PDGF signaling and enhancement of cell adhesiveness in cultured vascular smooth muscle cells. | |
| BCN3889 | Homogentisic acid |
| Homogentisic acid is the primary precursor of melanin synthesis in Vibrio cholerae, a Hyphomonas strain, and Shewanella colwelliana. Homogentisic acid shows interesting antioxidant and antiradical activities, and protective effect against thermal-cholesterol degradation. A derivative of homogentisic acid which inhibits Pfnek-1 with an IC(50) around 1.8 muM, this product is moderately active in vitro against a FcB1 P. falciparum strain (IC(50) = 12 muM). | |
| BCN3890 | Campestanol |
| 1. Campestanol, which shares the same basic structure and intestinal absorption pathway with cholesterol, does not accumulate when fed, and may be incorporated into the diet to block cholesterol absorption. | |
