Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN3892 | Cowaxanthone B |
| 1. Cowaxanthone B shows weak antibacterial activity. | |
| BCN3893 | Medicagenic acid |
| 1. Medicagenic acid derivatives exhibit potent fungistatic effects against several plant pathogens and human dermatophytes. 2. Medicagenic acid, the factor responsible for hemolytic activity of lucerne saponins. | |
| BCN3894 | Gliotoxin |
| 1. Gliotoxin targets nuclear NOTCH2 in human solid tumor derived cell lines in vitro and inhibits melanoma growth in xenograft mouse model. 2. Gliotoxin exhibits very strong anti-tuberculosis activity towards Mycobacterium tuberculosis with the the prominent MIC50 value of <0.03 uM. 3. Gliotoxin displays significant selective cytotoxicities against K562, A549 and Huh-7 cell lines with the IC50 values of 0.191, 0.015 and 95.4 uM, respectively. 4. Gliotoxin suppresses macrophage immune function by subverting phosphatidylinositol 3,4,5-trisphosphate homeostasis. 5. Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. | |
| BCN3895 | beta-Thujaplicin |
| 1. Hinokitiol can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent. 2. Hinokitiol has antibacterial effect , it can inhibit all Staphylococcus aureus isolates with MICs of 1.56-3.13 mg/L. 3. Hinokitiol has antifungal activity against 51 Malassezia pachydermatis strains, it is an inexpensive and safe treatment with anti-inflammatory and deodorant effects that can be recommended as an effective remedy for canine otitis externa. 4. beta-thujaplicin (Hinokitiol) has ability to extract mitochondrial Mg++ and the prevention of the effects of beta-thujaplicin by an excess of Mg++ in the medium, suggests a common mode of action of beta-thujaplicin as a lipophilic chelator of Mg++ and other divalent cations. | |
| BCN6379 | Cyclocurcumin |
| 1. Grossamide K exerts a particularly strong anti-melanogenic activity on the cells without high cell toxicity. | |
| BCN3898 | Cleomiscosin B |
| 1. Cleomiscosins A, B and C exhibit liver-protective properties. 2. Cleomiscosin B shows the potent anti-HIV-1 activity in vitro and also has protective effects on MT4 cells infected by HIV-1(IIIB). | |
| BCN3900 | Moschamine |
| 1. Moschamine may suppress cAMP formation via binding to 5-HT1 receptors in the cells. 2. Moschamine is a very potent compound that is able to inhibit COX-I by 58% and COX-II by 54%, at the concentration of 0.1 μmol L⁻1. 3. Moschamine exerts antitumour effects on HeLa, MCF7 and A431 cells. | |
| BCN3901 | cis-Moschamine |
| 1. cis-Moschamine exerts antitumour effects on HeLa, MCF7 and A431 cells. | |
