Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN8259 | Arjunglucoside I |
| 1. Arjunglucoside I has anti-inflammatory activity, it exhibits significant activity against carrageenan-induced paw edema in rat. 2. Arjunglucoside I shows antiproliferative activity against the A2780 human ovarian cancer cell line with an IC(50) value of 1.2 microM. | |
| BCN8260 | Poricoic acid B |
| 1. Poricoic acid B shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). 2. Poricoic acid B shows inhibitory activity against TPA-induced ear inflammatory oedema. | |
| BCN8263 | Kakkalide |
| 1. Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor. 2. Kakkalide attenuates ethanol-induced gastric injury in mice by inhibiting the infiltration of neutrophils. 3. Kakkalide can inhibit ROS-associated inflammation and ameliorated insulin-resistant endothelial dysfunction by beneficial effects on IRS-1 function. 4. Kakkalide has anti-inflammatory effects, it ameliorates carrageenan-induced inflammation in mice by inhibiting NF-κB pathway. 5. Kakkalide shows protective effects on ethanol-induced lethality and hepatic injury are dependent on its biotransformation by human intestinal microflora. | |
| BCN8265 | Obovatol |
| 1. Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects. 2. Obovatol is a potent NF-κB inhibitors for Alzheimer's disease treatment. 3. Obovatol shows inhibitory effect on the Salmonella type III secretion system, it could be useful for the prevention and supplementary treatment of bacterial infections. 4. Obovatol inhibits the growth and aggressiveness of tongue squamous cell carcinoma through regulation of the EGF-mediated JAK-STAT signaling pathway. 5. Obovatol induces apoptosis via CHOP activation in A549 and H460 NSCLCs. 6. Obovatol inhibits receptor activator of nuclear factor kappa B (NF-κB) ligand (RANKL)-induced osteoclast differentiation in vitro and inflammatory bone loss in vivo, it may be a useful therapeutic agent for the treatment of pathological bone disorders characterized by excessive osteoclastic bone resorption. 7. Obovatol shows neuroprotective effects against glutamate-induced apoptotic stimuli in HT22 cells. 8. Obovatol has a potent antithrombotic effect, which may be due to antiplatelet activity. 9. Obovatol inhibits vascular smooth muscle cell proliferation and intimal hyperplasia by inducing p21Cip1, it may have potential as an anti-proliferative agent for the treatment of restenosis and atherosclerosis. | |
| BCN8266 | Lonicerin |
| 1. Lonicerin has both anti-arthritic and antifungal activities, it can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection. 2. Lonicerin has potential antioxidant effects. | |
| BCN8267 | Poricoic acid G |
| 1. Poricoic acid G shows inhibition of tumor-promoting effects and cytotoxic activity. | |
| BCN8270 | Lucidumol A |
| 1. Lucidumol A has relatively good effect against aldose reductase with IC50 of 19.1uM. 2. Lucidumol A has cytotoxic activity, it reduced cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependently with LC50s from 20.87 to 84.36 uM. | |
| BCN8271 | Angelol M |
| 1. Angelol M shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells. | |
