Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN3844 | 6-Demethoxytangeretin |
| 1. 6-Demethoxytangeretin has anti-inflammatory activity, it also can suppress production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. 2. 6-Demethoxytangeretin can suppress the interleukin 1 (IL-1) induced production of proMMP-9/progelatinase B in rabbit synovial cells in a dose dependent manner (<64 microM). | |
| BCN3846 | Sotetsuflavone |
| 1. Sotetsuflavone , with an IC50 = 0.16 μM, is the most active compound of this series and is the strongest inhibitor of the Dengue virus NS5 RNA-dependent RNA polymerase . | |
| BCN8516 | Saikosaponin B4 |
| 1. Saikosaponin B4 can selectively inhibit ACTH-induced lipolysis. | |
| BCN8553 | Trans sodium crocetinate |
| 1. Trans sodium crocetinate (TSC) has been developed to enhance the delivery of oxygen to hypoxic tissues, TSC with temozolomide and radiation therapy for glioblastoma multiforme. 2. TSC provides neuroprotection against cerebral ischemia and reperfusion in obese mice. 3. TSC improves outcomes in rodent models of occlusive and hemorrhagic stroke. | |
| BCN3847 | Platycodin D2 |
| 1. Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice. 2. Platycodin D2 could be safely used as adjuvant eliciting Th1 and Th2 immune responses. 3. Polygalacin D2 exhibits significant inhibition on the proliferation of five kinds of cultured human tumor cell lines, i. e., A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro. | |
| BCN1552 | Cisplatin |
| 1. Cisplatin can enhance the cell-killing effect of radiation, an effect whose intensity varies with the schedule of administration. 2. The antitumor activity of the combination of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carhonyloxycamptothecin and CDDP(CPT-11) and cisplatin is superior to that of CPT-11 or cisplatin alone. 3. Cisplatin can induce acute kidney injury and neurotoxicity in rats. | |
| BCN8543 | Coniferyl ferulate |
| 1. Coniferyl ferulate can inhibit Glutathione S-transferase activity in a concentration-dependent manner and show a potential MDR reversal effect for antitumour adjuvant therapy. | |
| BCN8585 | Platycodin D3 |
| 1. Platycodin D3 exerts anti-Hepatitis C virus (HCV) activity. 2. Platycodin D3 could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway mucin. 3. Platycodin D3 is a NF-κB inhibitor. 4. Platycodin D3 can significantly enhance mitogen- and OVA-induced splenocyte proliferation in the OVA-immunized mice. | |
