Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN3833 | Panaxynol |
| Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation. Panaxynol has neuroprotective, and anti-proliferative effects, it induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms, and protects cortical neurons from ischemia-like injury by up-regulation of HIF-1alpha expression and inhibition of apoptotic cascade. Panaxynol has inhibitory effects on the proliferation of human pancreatic cancer cell PANC-1through inhibiting cell division and down-regulating Ki67 expression. | |
| BCN3834 | Streptozotocin |
| 1. Streptozotocin, which produces diabetes mellitus in experimental animals, has been reported to reduce the level of NAD in pancreatic isletsand to inhibit islet synthesis of proinsulin. 2. Streptozotocin can induce pancreatic insulitis, which is a new model of diabetes mellitus. | |
| BCN8609 | Gambogellic acid |
| 1. Gambogellic acid has cytotoxic activity, it exhibits inhibitory effect against SMMC-7221cell and A549 cell. | |
| BCN3835 | Kukoamine A |
| 1. Kukoamine A shows hypotensive activity. | |
| BCN3836 | Kukoamine B |
| 1. Kukoamine B is a potent dual inhibitor for both Lipopolysaccharides (LPS) and oligodeoxynucleotides containing CpG motifs (CpG DNA), LPS and CpG DNA are important pathogenic molecules for the induction of sepsis,are drug targets for sepsis treatment, thus kukoamine B is worthy of further investigation as a potential candidate to treat sepsis. 2. Kukoamine B inhibits inflammation in septic mice by reducing the concentrations of plasma LPS, decreasing leukocyte sequestration and interfering with NFκB activation, and, therefore, suppressing the proadhesive phenotype of endothelial cells. 3. Kukoamine B has protective effects against hydrogen peroxide (H2O2) induced cell injury and potential mechanisms in SH-SY5Y cells, it may potentially serve as an agent for prevention of several human neurodegenerative and other disorders caused by oxidative stress. | |
| BCN3837 | alpha-Asarone |
| 1. Alpha-Asarone shows insecticidal activity. | |
| BCN8454 | Corynoxine B |
| 1. Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA-HMGB1 interaction. 2. Corynoxine B exhibits prolongation of the thiopental-induced hypnosis on oral administration in mice. | |
| BCC8124 | Bacopasaponin C |
| 1. Bacopasaponin C may have antioxidant activity. 2. Bacopasaponin C shows anti-leishmanial property. | |
