Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1937 - 1944 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6342 | SB 204990 |
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ATP citrate lyase (ACLY) inhibitor. Prodrug of SB 201076. Inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells. Orally active in vivo.
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| BCC6343 | ML 289 |
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Selective negative allosteric modulator at mGlu3 receptors (IC50 = 660 nM). Exhibits 15-fold selectivity for mGlu3 over mGlu2. Centrally penetrant.
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| BCC6344 | Cystamine dihydrochloride |
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Transglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective.
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| BCC6345 | ML 337 |
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Selective negative allosteric modulator of mGlu<sub>3</sub> (IC<sub>50</sub> = 593 nM). Displays no activity at mGlu<sub>1</sub>, mGlu<sub>2</sub> or mGlu<sub>4-8</sub> at concentrations up to 30 <span class='symbol'>μ</span>M. Brain penetrant.
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| BCC6346 | ACT 335827 |
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Potent and selective orexin OX1 receptor antagonist (Kb values are 41 and 560 nM for OX1 and OX2 receptors respectively). Elicits anxiolytic effects in vivo. Brain penetrant and orally available.
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| BCC6347 | CK 869 |
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Inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization (IC<sub>50</sub>= 11 <span class='symbol'>μ</span>M). Does not inhibit budding or fission yeast Arp2/3 complexes.
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| BCC6348 | PMX 464 |
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Putative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system. Shown to inhibit Trx and induce a G1/S block in HT29 cells; inhibits cell proliferation in various colorectal cancer cell lines and MCF7 cells. Also elicits an anti-inflammatory response in A549 cells.
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| BCC6349 | INDY |
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DYRK1A/B inhibitor (IC<sub>50</sub> values are 0.23 and 0.24 <span class='symbol'>μ</span>M, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY.
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