Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN1327 | 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol |
| 1. 5α,8α-Epidioxyergosta-6,9(11),22-trien-3β-ol shows antimicrobial activity. | |
| BCN8278 | Brusatol |
| 1. Brusatol, a Nrf2 inhibitor, has dual anti-hepatitis C virus and anticancer effects and can enhance the comparable effects of sorafenib. 2. Brusatol is a new anti-pancreatic cancer adjuvant, 3. Brusatol-mediated inhibition of c-Myc/ROS signaling pathway increases HIF-1α degradation by promoting PHD activity and induces cell death in colorectal cancer under hypoxia. 4. Brusatol inhibits the response of cultured beta-cells to pro-inflammatory cytokines in vitro. 5. Brusatol shows antitrypanosomal activity against trypomastigotes of Trypanosoma evansi. | |
| BCN8589 | Hydroquinidine |
| 1. Hydroquinidine can prevents life-threatening arrhythmic events in patients with short QT syndrome. | |
| BCN8608 | Cnidicin |
| 1. Cnidicin exhibits a significant inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nervous system) and HCT-15 (colon) in vitro . 2. Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). | |
| BCN1456 | Aloe-emodin-8-O-beta-D-glucopyranoside |
| Aloe-emodin-8-O-beta-D-glucopyranoside shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro. | |
| BCN8646 | 14,15beta-Dihydroxyklaineanone |
| 1. 14,15beta-Dihydroxyklaineanone (IC(50) = 5 microM) shows anti-tumor promoting on tumor promoter-induced Epstein-Barr virus activation. 2. 14,15beta-Dihydroxyklaineanone is a plant growth inhibitor. | |
| BCN8606 | Toringin |
| 1. Toringin prevents the cis-effect of expanded CTG repeats in a stable PC12 cell transformant. | |
| BCN8563 | 3'-Demethylnobiletin |
| 1. 3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling proteins related with cell proliferation and cell death. 2. 3'-Demethylnobiletin significantly suppresses CD36 expression. | |
