Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1921 - 1928 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6326 | GaTx2 |
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Very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.
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| BCC6327 | Jingzhaotoxin III |
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Selective blocker of NaV1.5 channels (IC50 = 348 nM); displays no effect on other isoforms, including NaV1.2, NaV1.4, NaV1.6 and NaV1.7. Thought to inhibit sodium channel activation by binding to the NaV1.5 S3-S4 linker of domain II. Selectively inhibits the activation of cardiac sodium channels, but has no effect on sodium channels in dorsal root ganglion neurons.
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| BCC6328 | Phrixotoxin 3 |
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Potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV1.2, NaV1.3 and NaV1.5 respectively). Blocks inward sodium currents in a voltage-dependent manner.
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| BCC6329 | GSA 10 |
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Smoothened (Smo) receptor agonist (EC<sub>50</sub> = 1.2 <span class='symbol'>μ</span>M). Does not recognize the classic cyclopamine binding site. Does not promote Smo translocation to the primary cilium; is strongly potentiated by forskolin and cholera toxin. Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
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| BCC6330 | PG 106 |
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Selective hMC3 receptor antagonist (IC50 = 210 nM). Exhibits no activity at hMC4 receptors and hMC5 receptors.
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| BCC6331 | Methoxy-X04 |
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Fluorescent amyloid <span class='symbol'>β</span> (A<span class='symbol'>β</span>) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Displays high <em>in vitro</em> binding affinity (K<sub>i</sub> = 26.8 nM); binds selectively to fibrillar <span class='symbol'>β</span>-sheet deposits. Brain penetrant.
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| BCC6332 | Leukadherin 1 |
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Allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC<sub>50</sub> = 4 <span class='symbol'>μ</span>M). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces.
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| BCC6333 | Purotoxin 1 |
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Potent P2X3 receptor modulator (IC50 = 12 nM). Exhibits negligible effects on P2X2 and P2X2/3. Demonstrates antinociceptive properties in an animal model of inflammatory pain.
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