Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1881 - 1888 of 9359 hot products
| Catalog No. | Product Name |
|---|---|
| BCC6286 | BETP |
|
Selective positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor. Increases binding affinity of oxyntomodulin for the GLP-1 receptor. Potentiates oxyntomodulin-mediated GLP-1 receptor signaling in vitro and insulin secretion in vivo. Has no effect on GLP-2, GIP, PTH or glucagon receptors.
|
|
| BCC6287 | ANA 12 |
|
TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC<sub>50</sub> values are 45.6 nM and 41.1 <span class='symbol'>μ</span>M for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties.
|
|
| BCC6288 | Org 25543 hydrochloride |
|
Potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC<sub>50</sub> = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 <span class='symbol'>μ</span>M), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.
|
|
| BCC6289 | SA 47 |
|
Selective inhibitor of fatty acid amide hydrolase (FAAH). Exhibits greater selectivity for FAAH than URB 597 against multiple carboxylesterases.
|
|
| BCC6290 | NS 11021 |
|
Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.
|
|
| BCC6291 | Org 37684 |
|
Agonist of 5-HT2 receptors. Exhibits a rank order of potency of 5-HT2C >5-HT2B >5-HT2A (pEC50 values are 8.17, 7.96 and 7.11 respectively, in transfected CHO-K1 cells).
|
|
| BCC6292 | QNZ 46 |
|
NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC<sub>50</sub> values are 3, 6, 229, and >300, >300 <span class='symbol'>μ</span>M for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). Requires binding of glutamate to the GluN2 subunit.
|
|
| BCC6293 | CRANAD 2 |
|
Near-infrared probe that binds to A<span class='symbol'>β</span>40 aggregates (K<sub>d</sub> = 38 nM) and elicits an emission blue shift. Shown to bind to plaques in APP-PS1 transgenic mice, <em>in vitro</em>. Detects senile plaques in 19-month-old Tg2576 mice <em>in vivo</em>. Penetrates the blood-brain barrier.
|
|