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Hot Products

Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.

Hot products from the professional high-purity natural products manufacturer

Cat.No.	Product Name
BCC8116	Alloimperatorin
1. Alloimperatorin photosensitizes efficiently the hemolysis of erythrocytes. 2. Alloimperatorin exhibits in vitro antitumor activity in HL-60 acute myeloid leukemia cancer cells via inducing apoptosis, cell cycle disruption and inhibition of cell migration.
BCN8640	Hypaconine
1. Hypaconine exhibits strong cardiac activity.
BCN8639	Glabrone
1. Glabrone shows antiviral activity against influenza virus. 2. Glabrone exhibits significant PPAR-gamma ligand-binding activity.
BCN8684	Glabrol
1. Glabrol is a PTP1B inhibitor. 2. Glabrol is a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15 uM. 3. Glabrol has hypnotic effects, it induces sleep via a positive allosteric modulation of GABA(A)-BZD receptors. 4. Glabrol possesses significant antimicrobial activity in vitro. 5. Glabrol shows a noncompetitive type of inhibition against diacylglycerol acyltransferase (DGAT) with an IC50 value of 8.0 microM, it may have potential therapy for the treatment in obesity and type 2 diabetes patients.
BCN8450	Lindleyin
1. Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
BCC8171	Erigeroside
1. Erigeroside has the protective effects on cerebral ischemia-reperfusion injury in rat, its ability of anti-oxidation and scavenging oxidation free radical may be one of its protective mechanisms.
BCN8673	Pomiferin
1. Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. 2. Pomiferin has anticancer, antibacterial and antidiabetic properties. 3. Pomiferin has antiproliferative activity in normal (MCF-10A) and transformed (MCF-7) breast epithelial cells. 4. Pomiferin has anti-inflammatory and neuroprotective activities, it is effective in enhancing the activity of NSAID activated gene (NAG-1) at 2.5 pg/mL (1.5-1.8 fold increase) and inhibiting iNOS and NF-κB activity with IC50 values in the range of 6-13 ug/mL. 5. Pomiferin has protection on kidney ischaemia-reperfusion injury in rats.
BCN8466	Aloperine
1. Aloperine has antitumor effects , it can suppress the tumor growth and promote cell apoptosis and cell cycle arrest in PCa cells. 2. Aloperine protects mice against bleomycin-induced pulmonary fibrosis by attenuating fibroblast proliferation and differentiation. 3. Aloperine exhibits neuroprotective effects against oxidative stress in vitro, it can ameliorate oxidative damage against early brain injury following subarachnoid hemorrhage , most likely via the Nrf2-ARE survival pathway. 4. Aloperine attenuates hydrogen peroxide-induced injury via anti-apoptotic activity and suppression of the nuclear factor-κB signaling pathway. 5. Aloperine exerts significant inhibitive effects on acute inflammation and Type III and IV hypersensitivity caused by a variety of inflammatory agents.