Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1849 - 1856 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6254 | SMANT hydrochloride |
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Inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC<sub>50</sub> = 1.1 <span class='symbol'>μ</span>M). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.
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| BCC6255 | ProTx I |
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Selective Ca<sub>V</sub>3.1 channel blocker (IC<sub>50</sub> values are 0.2 and 31.8 <span class='symbol'>μ</span>M for hCa<sub>V</sub>3.1 and hCa<sub>V</sub>3.2 respectively). Also reversibly inhibits Na<sub>V</sub>1.8 and blocks K<sub>V</sub>2.1 channels.
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| BCC6256 | SB 706375 |
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High affinity, non-peptide antagonist of the urotensin-II (UT) receptor. Exhibits high affinity for mammalian UT receptors, including human, mouse and rat (Ki values are 9.3, 19.1 and 20.7 nM respectively, in HEK293 cells expressing recombinant UT receptors). Also inhibits binding of radiolabeled urotensin to endogenous human UT receptors (Ki = 5.4 nM in a whole-cell binding assay). Displays ≥100-fold selectivity for the human UT receptor over 86 different receptors, ion channels, enzymes, transporters and nuclear hormones.
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| BCC6257 | SB 611812 |
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Urotensin-II (UT) antagonist. Inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. Attenuates cardiac dysfunction in a rat model of coronary artery ligation; decreases cardiomyocyte hypertrophy, ventricular dilatation and cardiac remodeling.
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| BCC6258 | CCT 031374 hydrobromide |
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Inhibitor of TCF-dependent transcription. Blocks BIO</a>-induced <span class='symbol'>β</span>-catenin stabilization; reduces nuclear and cytosolic <span class='symbol'>β</span>-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.
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| BCC6259 | CYM 50260 |
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Potent sphingosine-1-phosphate receptor 4 (S1P<sub>4</sub>) agonist (EC<sub>50</sub> = 45 nM). Displays no activity at other S1P receptor subtypes (S1P<sub>1-3</sub> and S1P<sub>5</sub>) at concentrations up to 25 <span class='symbol'>μ</span>M.
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| BCC6260 | CYM 50308 |
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Potent and selective sphingosine-1-phosphate receptor 4 (S1P<sub>4</sub>) agonist (EC<sub>50</sub> values are 56 nM and 2100 nM for S1P<sub>4</sub> and S1P<sub>5</sub> receptors, respectively). Displays no activity at S1P<sub>1</sub>, S1P<sub>2</sub> and S1P<sub>3</sub> receptors at concentrations up to 25 <span class='symbol'>μ</span>M.
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| BCC6261 | RFRP 3 (human) |
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Agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.
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