Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1809 - 1816 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6214 | TAS 301 |
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Inhibitor of smooth muscle cell migration and proliferation. Blocks voltage-independent calcium influx and downstream PKC signaling. Inhibits neointimal thickening after balloon catheter injury to the rat common carotid artery.
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| BCC6215 | Piclamilast |
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Potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 1 nM at PDE4 from human neutrophils). Displays >19,000-fold selectivity over other PDE isoenzymes. Exhibits anti-inflammatory effects in models of allergic inflammation. Also inhibits LTB4 synthesis in human neutrophils (IC50 = 2 nM).
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| BCC6216 | TC-I 15 |
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Potent <span class='symbol'>α</span><sub>2</sub><span class='symbol'>β</span><sub>1</sub> integrin inhibitor (IC<sub>50</sub> values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). Displays selectivity for <span class='symbol'>α</span><sub>2</sub><span class='symbol'>β</span><sub>1</sub> over <span class='symbol'>α</span><sub>v</sub><span class='symbol'>β</span><sub>3</sub>, <span class='symbol'>α</span><sub>5</sub><span class='symbol'>β</span><sub>1</sub>, <span class='symbol'>α</span><sub>6</sub><span class='symbol'>β</span><sub>1</sub> and <span class='symbol'>α</span><sub>IIb</sub><span class='symbol'>β</span><sub>3</sub> at concentrations exceeding 1000 nM. Reduces collagen IV production in mesangial cells. Active <em>in vivo</em>; prevents ferric chloride-induced clot formation in mice.
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| BCC6217 | PTAC oxalate |
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Muscarinic receptor ligand. Displays partial agonist activity at M2 and M4 receptors; exhibits antagonist effects at M1, M3 and M5 receptors (Ki values are 2.8, 0.2, 0.6, 0.2 and 0.8 nM respectively). Displays selectivity for muscarinic receptors over a range of neurotransmitter receptors and ion channels. Inhibits firing rate of dopaminergic cells in the limbic ventral tegmental area after acute administration, without binding to dopamine receptors.
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| BCC6218 | CZC 54252 hydrochloride |
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Potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM).
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| BCC6219 | NCX 466 |
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Cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor (CINOD). Inhibits COX-1 and COX-2 while releasing NO. Demonstrates higher efficacy than naproxen, its congener drug, in reducing levels of profibrotic cytokine transforming growth factor-<span class='symbol'>β</span> and oxidative stress in a mouse model of bleomycin-induced lung fibrosis. Orally available.
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| BCC6220 | T16Ainh - A01 |
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Inhibitor of Ca<sup>2+</sup>-dependent Cl<sup>-</sup> channel (CaCC) transmembrane protein 16A (TMEM16A) (IC<sub>50</sub> = 1.8 <span class='symbol'>μ</span>M in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells <em>in vitro</em>.
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| BCC6221 | CS 2100 |
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Sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 4.0 nM). Exhibits 5000-fold selectivity for human S1P1 over S1P3. Displays efficacy in a rat adjuvant-induced arthritis model.
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