Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN6424 | Minimolide F |
| 1. Minimolide F displays inhibitory activity against human nasopharyngeal cancer cells (CNE) with IC(50) values ranging from 1.1 to 20.3 uM. | |
| BCN7924 | Mogroside IIIe |
| 1. Mogroside IIIe has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AMPK activation. 2. Mogroside IIIe has anti-fibrotic activity, it reduces pulmonary fibrosis through Toll-Like receptor 4 pathways. | |
| BCN7925 | Mogroside III-A2 |
| 1. Mogroside III-A2 exhibits inhibitory effects with IC50 values of 346-400 mol ratio/32 pmol TPA. and shows weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor. | |
| BCN7926 | Mogroside II-A1 |
| 1. Mogroside II-A1 exhibits inhibitory effects with IC50 values of 346-400 mol ratio/32 pmol TPA. and shows weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor. | |
| BCN7927 | Trilobinine |
| 1. (+)-Trilobinine has relaxant effects via the activation of beta 2-adrenoceptors, it can reduce the spontaneous tone and inhibit the contractions induced by carbachol and histamine. | |
| BCN7929 | 5-O-Caffeoylshikimic acid |
| 1. 5-O-Caffeoylshikimic acid shows moderate MDR reversal activity. 2. 5-O-Caffeoylshikimic acid shows anti-oxidative activity . 3. 5-O-Caffeoylshikimic acid can remarkably inhibit the macrophage migration and adhesion. 4. 5-O-Caffeoylshikimic acid has anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB. | |
| BCN7930 | 3-O-Caffeoylshikimic acid |
| 1. 3-O-Caffeoylshikimic acid shows anti-oxidative activity . 2. 3-O-Caffeoylshikimic acid shows potent antiproliferative activities with IC(50) values among 5-150 μM against HepG2 human liver cancer, HL-60 human myeloid leukemia, K562 human myeloid leukemia, and CNE-1 human nasopharyngeal carcinoma cell lines. | |
| BCN7934 | Isoatriplicolide tiglate |
| 1. Isoatriplicolide tiglate acts as an antiproliferation agents particularly against breast and cervical cancers by inducing cell cycle arrest in the S/G2 phase and caspase dependent apoptosis at relatively low (< 10 μg/mL) and high (> 50 μg/mL) concentrations, respectively. 2. Isoatriplicolide tiglate exhibited significant neuroprotective activity against glutamate-induced toxicity at concentrations ranging from 1 uM to 10 uM. | |
