Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1785 - 1792 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6189 | TC-S 7005 |
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Potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC50 values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.
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| BCC6190 | NS 3623 |
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KV11.1 (hERG) and KV4.3 channel activator. Activates the IKr and Ito currents and displays antiarrhythmic activity. May also act as a partial blocker of KV11.1 channels. Displays selectivity over the key cardiac potassium channels, KV7.1 (KCNQ1) and KV1.5. Suitable for both in vitro and in vivo use.
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| BCC6191 | SR 8278 |
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Rev-Erb<span class='symbol'>α</span> antagonist; inhibits Rev-Erb<span class='symbol'>α</span> transcriptional repression (EC<sub>50</sub> = 0.47 <span class='symbol'>μ</span>M). Blocks activity of Rev-Erb<span class='symbol'>α</span> agonist GSK 4112 in HEK293 cells. Increases expression of glucose-regulating genes, <em>G6Pase</em> and <em>PEPCK</em> in HepG2 cells.
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| BCC6192 | IOX 1 |
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Histone demethylase JMJD inhibitor (IC<sub>50</sub> values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 <span class='symbol'>μ</span>M for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells.
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| BCC6193 | PHP 501 trifluoroacetate |
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Potent GABA<sub>A</sub> antagonist (K<sub>i</sub> = 0.0028 <span class='symbol'>μ</span>M at rat GABA<sub>A</sub> receptors; IC<sub>50</sub> = 0.024 <span class='symbol'>μ</span>M at human <span class='symbol'>α</span><sub>1</sub><span class='symbol'>β</span><sub>2</sub><span class='symbol'>γ</span><sub>2</sub> GABA<sub>A</sub>-expressing tsA201 cells). Displays no inhibitory activity at hGAT-1, hGAT-2, hGAT-3 or hBGT-1 GABA transporters.
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| BCC6194 | AT 1015 |
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Long-acting 5-HT2A receptor antagonist; inhibits vasoconstriction and blocks platelet aggregation. Prolongs clotting time in a rat model of thrombus formation; ameliorates laurate-induced peripheral vascular lesions in rodents.
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| BCC6196 | DMH4 |
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Selective VEGFR-2 inhibitor (IC<sub>50</sub> values are 161, 3558, 8038 and > 30000 nM for VEGFR-2, BMPR-I, AMPK and TGF<span class='symbol'>β</span>R-I respectively). Displays antiangiogenic activity <em>in vitro</em> and <em>in vivo</em>.
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| BCC6197 | BAY 60-6583 |
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Potent adenosine A2B receptor agonist (EC50 = 2.83 nM for murine A2B receptor). Displays selectivity for A2B over A1, A2A and A3 receptors. Decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Cardioprotective; attenuates infarct size in a mouse model of myocardial ischemia.
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