Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN3758 | 4',7-Dihydroxyflavone |
| 1. 4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. 2. 4',7-Dihydroxyflavone has inhibitory activities against COX-2. | |
| BCN3762 | Coronaridine |
| 1. Coronaridine is an antitumor agent. 2. Coronaridine congeners inhibit hα3β4 AChRs by blocking the ion channel's lumen and probably by additional negative allosteric mechanisms by interacting with a series of non-luminal sites. | |
| BCN3763 | (-)-Bicuculline methochloride |
| 1. (-)-Bicuculline methochloride is a GABAA-receptor antagonist. 2. Exposure to 100 microM (-)-Bicuculline methochloride for 48 hr can result in prominent CA1 cell death. | |
| BCN3764 | Kansuiphorin C |
| 1. Kansuiphorin C shows cytotoxic activity. | |
| BCN1382 | 3-O-(2'E ,4'Z-decadienoyl)-20-deoxyingenol |
| 1. 3-O-(2'E ,4'Z-decadienoyl)-20-deoxyingenol, one toxic terpenoid from raw Gansui. 2. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol has strong cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships. 3. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetyl-ingenol and 3-O-(2′E,4′E-decadienoyl)-ingenol show cytotoxicity on Namalwa cells with IC 50 values of 7.6 and 5.2 umol·L-1, respectively. | |
| BCN3765 | Kansuinine A |
| 1. Kansuinine A possesses analgesic props. 2. Kansuinine A shows NGF inducing activity. | |
| BCN1550 | 3-O-(2'E ,4'Z-decadienoyl)-20-O-acetylingenol |
| 1. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol, one toxic terpenoid from raw Gansui. 2. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol has strong cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships . 3. 20-O-acetyl-[3-O-(2'E,4'Z)-decadienoyl]-ingenol and 3-O-(2'E,4'Z)-decadienoylingenol show the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 microg/cotton ball. 4. 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol induces the cytotoxicity of intestinal epithelial cells of rats (IEC-6 cells) depends on induction of cell apoptosis via mitochondrial pathway and cell cycle arrest. 5. 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol, kansuinine B and kansuinine A can markedly promote SPL proliferation and NO production by PMphi at concentrations from 0.78 to 12.50 microg/mL, hence the they are believed to be important proinflammatory components of the roots of E. kansui. | |
| BCN1437 | 3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol |
| 1. 3-O-(2′E,4′E-decadienoyl)-20-O-acetylingenol has strong cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships. | |
