Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN3698 | Isoderrone |
| 1. Isoderrone is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with IC50 value of 22.7 ± 1.7 uM, suggests that it may be a new drug for treatment of type 2 diabetes. 2. Isoderrone shows inhibitory effects on α-glucosidase in vitro. | |
| BCN3699 | Yukovanol |
| 1. Yukovanol inhibits the proliferation of activated HSC-T6 cells in vitro. | |
| BCN3700 | (20R)-Ginsenoside Rh1 |
| (20R)-Ginsenoside Rh1 exhibits various pharmacological activities including vasorelaxation, antioxidation, anti-inflammation, and anticancer. | |
| BCN3701 | Panaxydol |
| Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through NADPH oxidase and mitochondria. It induces the differentiation in C6 cells, may through a PI 3-K-dependent pathway. | |
| BCN3702 | Panaxydiol |
| 1. Panaxydiol can inhibit rat liver cholesterol acyltransferase (ACAT) with IC50 values of 45 microM. | |
| BCN3705 | Inulanolide A |
| 1. Inulanolide A has potent cytotoxicity. 2. Inulanolide A is a novel NFAT1 and MDM2 dual targeting agent and may be a clinical candidate for breast cancer therapy. | |
| BCN3706 | 14-Deoxyandrographolide |
| 1. 14-Deoxyandrographolide desensitizes hepatocytes to TNF-alpha-mediated apoptosis through the release of TNFRSF1A. 2. 14-Deoxyandrographolide has hepatoprotective activity, mediates activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS, may provide a promising approach in the prevention of liver diseases during chronic alcoholism. | |
| BCN3707 | Delta3,2-Hydroxylbakuchiol |
| 1. Delta3,2-Hydroxylbakuchiol acts by protecting dopaminergic neurons from MPP(+) injury and preventing against MPTP-induced behavioral and histological lesions in the Parkinson's disease (PD) model, possibly by inhibiting monoamine transporters. 2. Delta3,2-Hydroxylbakuchiol, a monoamine transporter inhibitor involved in regulating dopaminergic and noradrenergic neurotransmission and may have represented potential pharmacotherapies for disorders such as Parkinson's disease, depression, and cocaine addiction. | |
