Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1745 - 1752 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6149 | TC-MCH 7c |
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Potent, selective melanin-concentrating hormone receptor 1 (MCH<sub>1</sub>R) antagonist (IC<sub>50</sub>= 5.6 nM in hMCH<sub>1</sub>R-expressing CHO cells). Displays selectivity for MCH<sub>1</sub>R over MCH<sub>2</sub>R (IC<sub>50</sub> = > 10 <span class='symbol'>μ</span>M). Decreases body weight in a mouse model of diet-induced obesity. Brain penetrant; orally active.
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| BCC6150 | TC-N 22A |
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Potent and selective mGlu<sub>4</sub> receptor positive allosteric modulator (EC<sub>50</sub> = 9 nM in human mGlu<sub>4</sub>-expressing BHK cells). Selective for mGlu<sub>4</sub> over mGlu<sub>1</sub>, mGlu<sub>2</sub>, mGlu<sub>3</sub>, mGlu<sub>5</sub> and mGlu<sub>7</sub> receptors (EC<sub>50</sub> values are > 10 <span class='symbol'>μ</span>M). Brain penetrant.
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| BCC6151 | CMPDA |
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Positive allosteric modulator of GluA2 receptors (EC50 values are 45.4 and 63.4 nM at GluA2i and GluA2o respectively, in a calcium influx screening assay). Binds at the modulator binding pocket located at the interdimer interface and the clamshell hinges.
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| BCC6152 | SMER 3 |
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Selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCF<sup>Met30</sup>) <em>in vitro </em>and <em>in vivo</em>. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin.
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| BCC6153 | 5-OMe-UDP trisodium salt |
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Potent P2Y<sub>6</sub> agonist (EC<sub>50</sub> = 0.08 <span class='symbol'>μ</span>M). Displays greater potency at P2Y<sub>6</sub> than UDP (EC<sub>50</sub> = 0.14 <span class='symbol'>μ</span>M).
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| BCC6154 | VU 0285683 |
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Negative allosteric modulator of mGlu<sub>5</sub> receptors. Displays high affinity for the MPEP binding site; acts as a full antagonist and blocks the glutamate response to mGlu<sub>5</sub> (IC<sub>50</sub> = 24.4 nM). Selective for mGlu<sub>5</sub> over mGlu<sub>1</sub>, mGlu<sub>3</sub> and mGlu<sub>4</sub>. Exhibits anxiolytic activity in rodent models of anxiety. Analog</a> available .
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| BCC6155 | TC-P 262 |
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Selective P2X3 and P2X2/3 receptor antagonist (pIC50 values are 7.39 and 6.68 respectively). Displays no detectable activity at P2X1, P2X2, P2X4 and P2X7 receptors (pIC50 < 4.7).
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| BCC6156 | MNI 137 |
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Selective negative allosteric modulator of group II mGlu receptors (IC50 values are 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization). Displays no activity at mGlu1, mGlu4, mGlu5 or mGlu8 receptors in a calcium mobilization assay.
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