Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN3639 | Toddaculine |
| 1. Toddaculine can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. 2. Toddaculine may be beneficial for the prevention and treatment of osteoporosis. 3. Toddaculine displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells, suggesting it may serve as a pharmacological prototype for the development of novel anti-leukemic agents. | |
| BCN3640 | Toddacoumaquinone |
| 1. Toddacoumaquinone shows a weak activity (EC50 = 10 micrograms/ml) against HSV-1 and HSV-2. | |
| BCN3641 | N-Methylflindersine |
| 1. N-Methylflindersine shows strong toxicity towards brine shrimp larvae, with an LD(50) value of 1.39 microg/ml. 2. N-Methylflindersine exhibits potent inhibition against N -formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM. | |
| BCN3643 | Norchelerythrine |
| 1. Norchelerythrine shows significant inhibitory activity against Staphylococcus aureus ATCC 6538 with MIC values ranging from 12.5 to 50 ug/mL. 2. Norchelerythrine exhibits strong antifeeding activity in a concentration-dependant manner with the EC50 of 62.67 ppm. | |
| BCN3645 | Polyporenic acid C |
| 1. Polyporenic acid C shows inhibitory activity against human collagenase. 2. Polyporenic acid C induces apoptosis through the death receptor-mediated apoptotic pathway where the activation of caspase-8 leads to the direct cleavage of execution caspases without the involvement of the mitochondria. | |
| BCN3646 | Dehydroeburicoic acid |
| 1. Dehydroeburicoic acid treatment resulted in a marked decrease of tumor weight and size without any significant decrease in mice body weights. 2. Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas. 3. Dehydroeburicoic acid and Eburicoic acid have antioxidant and anti-inflammatory activities by the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity, can protect the liver from CCl4-induced hepatic damage. | |
| BCN3648 | Dehydropachymic acid |
| 1. Dehydropachymic acid shows antiinflammatory activity. | |
| BCN3649 | 3-Epidehydrotumulosic acid |
| 1. 3-Epidehydrotumulosic acid has inhibitory activity against AAPH-induced lysis of red blood cells. | |
