Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1697 - 1704 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6099 | IDE 2 |
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Cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC<sub>50</sub> = 223 nM for induction of Sox17 expression in ESCs). Reported to activate TGF-<span class='symbol'>β</span> signaling and downstream Smad2 phosphorylation; upregulates <em>Nodal</em> expression. Promotes pancreatic progenitor cell formation <em>in vitro</em>, and gut tube formation <em>in vivo</em>.
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| BCC6100 | JNJ 5207787 |
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Selective NPY Y<sub>2</sub> antagonist (IC<sub>50</sub> = 0.1 <span class='symbol'>μ</span>M). Displays 100-fold selectivity over NPY Y<sub>1</sub>, Y<sub>4</sub> and Y<sub>5</sub> receptors; also displays selectivity against a panel of 50 receptors, ion channels and transporters. Brain penetrant.
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| BCC6101 | JNJ 5207852 dihydrochloride |
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High affinity histamine H<sub>3</sub> receptor neutral antagonist (pK<sub>i</sub> values are 8.9 and 9.2 in rat and human respectively). Brain penetrant and orally active. Has 3- and 100-fold higher affinity than thioperamide for rat and human H<sub>3</sub> receptors respectively. Suppresses slow-wave sleep; exhibits wake-promoting effects in rodent arousal models.
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| BCC6102 | ES 936 |
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Mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase (NQO1). Induces growth inhibition in human pancreatic carcinoma (MIA PaCa-2) and adenocarcinoma (BxPC-3) cell lines with IC50 values of 108 and 365 nM respectively. Also inhibits TNF-α-induced E-selectin protein expression in human bone marrow endothelial cells. Exhibits no effects on other cellular reductases or levels of acid-soluble thiols.
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| BCC6103 | ProTx II |
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Selective NaV1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
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| BCC6104 | 5'-Fluoroindirubinoxime |
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Inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC50 = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).
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| BCC6105 | PM 102 |
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Peptide that reverses the anticoagulant effect of heparin. Potently binds heparin (K<sub>d</sub> = 36 nM <em>in vitro</em>).
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| BCC6106 | MRE 3008F20 |
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Potent adenosine A3 receptor competitive antagonist. Selective for human A3 receptors over human A1 and A2A receptors (Ki values are 0.29, 141 and 1197 nM respectively). Potently inhibits agonist-induced cyclic AMP elevation in resting T lymphocytes (IC50 = 5 nM).
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