Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1641 - 1648 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6043 | CRSP-1 |
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Endogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED50 values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related peptide (CGRP) and adrenomedullin receptors. Inhibits formation of multinuclear osteoclasts with similar efficacy to CT in vitro. Suppresses food intake and increases body temperature in free-feeding rats, and significantly decreases plasma calcium levels in vivo.
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| BCC6044 | RuBi-4AP |
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Water soluble ruthenium-bipyridine-triphenylphosphine caged 4-aminopyridine (4-AP). Excited by visible wavelengths and has two-photon uncaging capabilities under physiological conditions. Releases 4-AP, a voltage-dependent K<sup>+</sup> channel blocker.
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| BCC6045 | G-1 |
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Potent and selective GPER agonist (K<sub>i</sub> = 11 nM, EC<sub>50</sub> = 2 nM); displays no activity at ER<span class='symbol'>α</span> and ER<span class='symbol'>β</span> at concentrations up to 10 <span class='symbol'>μ</span>M. Increases cytosolic Ca<sup>2+</sup> and inhibits migration of SKBr3 cells and MCF-7 cells in response to chemoattractants (IC<sub>50</sub> values are 0.7 and 1.6 nM respectively) <em>in vitro</em>. Blocks MCF-1 cell cycle progression at the G<sub>1</sub> phase. Displays therapeutic effects in the mouse EAE model of multiple sclerosis.
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| BCC6046 | HKI 357 |
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Potent, irreversible inhibitor of ErbB2 (HER2) and EGFR (IC<sub>50</sub> values are 33 and 34 nM respectively). Suppresses ligand-induced EGFR autophosphorylation and cell proliferation in NCI-H1975 cells containing L858R and T790M mutations. Circumvents mechanisms of resistance to Iressa in non-small-cell lung cancer cells.
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| BCC6047 | C 021 dihydrochloride |
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Potent CCR4 chemokine receptor antagonist (IC<sub>50</sub> values are 0.14 and 0.039 <span class='symbol'>μ</span>M for inhibition of chemotaxis in human and mouse respectively).
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| BCC6048 | GRK2i |
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GRK2 inhibitory polypeptide that specifically inhibits G<span class='symbol'>βγ</span> activation of GRK2. Corresponds to the G<span class='symbol'>βγ</span>-binding domain and acts as a cellular G<span class='symbol'>βγ</span> antagonist.
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| BCC6049 | Lys-γ3-MSH |
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Pro-opiomelanocortin (POMC) derived peptide. Potentiates the steriodogenic action of corticotrophin on the adrenal cortex, possibly via the MC3 receptor. Potently stimulates lipolysis via activation of hormone-sensitive lipase (HSL).
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| BCC6050 | Enterostatin |
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N' terminal peptide fragment of procolipase that binds to the β-subunit of F1-ATPase. Activates the ERK and cAMP signaling pathways, and downregulates expression of Krüppel-like factor 4 (KLF4) and agouti-related peptide (AgRP) in vitro. Inhibits insulin secretion from pancreatic β-cells by downregulating expression of dynamin2 and altering protein trafficking. Reduces dietary fat intake via activation of CCK1, induces satiety, enhances memory-consolidation and exhibits hypocholesterolemic activity in vivo. Orally active.
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