Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1585 - 1592 of 9359 hot products
| Catalog No. | Product Name |
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| BCC5986 | Mirin |
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Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC<sub>50</sub> = 12 <span class='symbol'>μ</span>M) and induces G<sub>2</sub> cell cycle arrest. Also blocks homology-directed repair <em>in vitro</em>.
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| BCC5987 | Dynorphin B |
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Opioid peptide that is the preferred endogenous agonist for the kappa opioid receptor. Displays moderate selectivity for <span class='symbol'>κ</span><sub>1b</sub>.
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| BCC5988 | Echistatin, α1 isoform |
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Potent irreversible <span class='symbol'>α</span><sub>V</sub><span class='symbol'>β</span><sub>3</sub> integrin antagonist (K<sub>i</sub> = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC<sub>50</sub> = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, <span class='symbol'>α</span><sub>IIb</sub><span class='symbol'>β</span><sub>3</sub>) receptors (IC<sub>50</sub> = 30 nM) <em>in vitro</em>.
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| BCC5989 | ACV 1 |
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Neuronal nicotinic receptor antagonist that displays selectivity for the <span class='symbol'>α</span>9<span class='symbol'>α</span>10 subtype (IC<sub>50</sub> values are 19, 140, 980, 4200 and 7300 nM for <span class='symbol'>α</span>9<span class='symbol'>α</span>10, <span class='symbol'>α</span>6/<span class='symbol'>α</span>3<span class='symbol'>β</span>2<span class='symbol'>β</span>3, <span class='symbol'>α</span>6/<span class='symbol'>α</span>3<span class='symbol'>β</span>4, <span class='symbol'>α</span>3<span class='symbol'>β</span>4 and <span class='symbol'>α</span>3<span class='symbol'>β</span>2 subtypes respectively). Alleviates neuropathic pain in three rat models of human neuropathic pain and accelerates functional recovery of injured neurons.
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| BCC5990 | ShK-Dap22 |
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Extremely potent K<sub>V</sub>1.3 channel blocker (K<sub>d</sub> = 23 pM for mK<sub>V</sub>1.3 currents). Selective for K<sub>V</sub>1.3 over other mammalian potassium channels (IC<sub>50</sub> values are 23, 1800, 10500, 37000 and 39000 pM for mK<sub>V</sub>1.3, mK<sub>V</sub>1.1, hK<sub>V</sub>1.6, mK<sub>V</sub>1.4 and rK<sub>V</sub>1.2 respectively, and >100000 pM for hK<sub>V</sub>1.5, mK<sub>V</sub>1.7, hK<sub>V</sub>3.1, rK<sub>V</sub>3.4 and hK<sub>Ca</sub>4). Suppresses T cell activation <em>in vitro</em> (IC<sub>50</sub> < 500 pM).
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| BCC5991 | Lys-[Des-Arg9]Bradykinin |
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Endogenous potent and highly selective bradykinin B<sub>1</sub> receptor agonist (K<sub>i</sub> values are 0.12 and > 30000 nM at human B<sub>1</sub> and B<sub>2</sub> receptors respectively). Hypotensive agent that reduces peripheral vascular resistance <em>in vivo</em>. 16-fold more potent than [Des-Arg<sup>9</sup>]-Bradykinin.
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| BCC5992 | R 892 |
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Potent and selective bradykinin B<sub>1</sub> receptor antagonist (ID<sub>50</sub> values are 2.8 and > 600 nM at B<sub>1</sub> and B<sub>2</sub> receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity <em>in vivo</em>.
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| BCC5993 | Lys-Bradykinin |
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Endogenous bradykinin receptor agonist that displays some selectivity for the B<sub>2</sub> receptor (K<sub>i</sub> values are 2.54 and 0.63 nM at human B<sub>1</sub> and B<sub>2</sub> receptors respectively). Hypotensive agent that reduces peripheral vascular resistance <em>in vivo</em>. Twice as potent as bradykinin <em>in vivo</em>.
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