Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1609 - 1616 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6010 | Cortistatin 14 |
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Endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst<sub>1</sub> - sst<sub>5</sub>) and prevents somatostatin-14 binding (IC<sub>50</sub> values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst<sub>1</sub>, sst<sub>2</sub>, sst<sub>3</sub>, sst<sub>4</sub> and sst<sub>5</sub> receptors respectively). Also binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties <em>in vivo</em>.
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| BCC6011 | (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin |
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Selective vasopressin V<sub>1A</sub> receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations <em>in vitro</em> (IC<sub>50</sub> values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus <em>in vivo</em>.
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| BCC6012 | RuBi-GABA |
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Ruthenium-bipyridine-triphenylphosphine caged GABA that is excited by visible wavelengths. Provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Produces GABA receptor-mediated currents in pyramidal neurons <em>in vitro</em> and displays no effect on endogenous GABAergic or glutamatergic transmission at concentrations effective for uncaging.
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| BCC6013 | GLYX 13 |
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NMDA receptor partial agonist that acts at the glycine site. Simultaneously acts as a promoter of the induction of long-term potentiation (LTP) and as a suppressor of long-term depression (LTD). Exhibits nootropic, neuroprotective and antinociceptive activity, and enhances learning, memory and cognition <em>in vivo</em>. Brain penetrant.
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| BCC6014 | R 715 |
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Potent and selective bradykinin B<sub>1</sub> receptor antagonist (pA<sub>2</sub> = 8.49). Displays no activity at B<sub>2</sub> receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.
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| BCC6016 | CP 99994 dihydrochloride |
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High affinity NK<sub>1</sub> antagonist (K<sub>i</sub> = 0.145 nM <em>in vitro</em>). Also displays high <em>ex vivo</em> binding potency in gerbil striatum (IC<sub>50</sub> = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.
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| BCC6017 | Amylin |
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Endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors. Inhibits glucagon secretion, delays gastric emptying and acts as a satiety agent. Displays glucose lowering effects <em>in vivo</em>.
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| BCC6018 | AC 187 |
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Orally active, potent amylin receptor antagonist (IC<sub>50</sub> = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid <span class='symbol'>β</span>-induced neurotoxicity by attenuating the activation of initiator and effector caspases <em>in vitro</em>. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake <em>in vivo</em>.
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