Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1649 - 1656 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6051 | Novokinin |
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Angiotensin AT<sub>2</sub> receptor agonist (K<sub>i</sub> = 7.35 <span class='symbol'>μ</span>M) that displays 93-fold selectivity over AT<sub>1</sub>. Exhibits vasorelaxing and hypotensive activity via activation of the IP (prostacyclin) receptor, and suppresses food intake via activation of PGE<sub>2</sub>-EP<sub>4</sub>. Orally active.
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| BCC6052 | UBP 310 |
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GLU<sub>K5</sub> kainate receptor antagonist (IC<sub>50</sub> = 130 nM); also blocks recombinant homomeric GLU<sub>K7</sub> receptors. Displays 12,700-fold selectivity for GLU<sub>K5</sub> over GLU<sub>K6</sub>. Exhibits no activity at mGlu group I or NMDA receptors at concentrations of up to 10 <span class='symbol'>μ</span>M. Apparent K<sub>D</sub> value is 18 ± 4 nM for depression of kainate responses on the dorsal root.
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| BCC6053 | M 1145 |
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Potent and selective galanin receptor 2 (GAL2) agonist (EC50 = 38 nM, Ki values are 6.55, 497 and 587 nM at GAL2, GAL3 and GAL1 respectively). Has an additive effect on the signal transduction of galanin.
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| BCC6054 | Neuropeptide SF (mouse, rat) |
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Neuropeptide FF receptor agonist (K<sub>i</sub> values are 48.4 and 12.1 nM for NPFF1 and NPFF2, respectively). Potentiates the antinociceptive action of morphine <em>in vivo</em> and reverses the loss of morphine potency in tolerant animals. Also increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) (EC<sub>50</sub> ~ 50 <span class = 'symbol'>μ</span>M).
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| BCC6055 | Neuromedin S (rat) |
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Potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Induces phase shifts in the circadian rhythm of locomotor activity following i.c.v. administration. Potent endogenous anorexigenic peptide.
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| BCC6056 | SB 328437 |
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Potent and selective CCR3 antagonist (IC50 = 4 nM). Displays > 2500-fold selectivity over C5aR, LTD4, CCR7, CXCR1 and CXCR2 receptors. Inhibits eotaxin-, eotaxin-2- and MCP-4-induced Ca2+ mobilization (IC50 values are 38, 35 and 20 nM respectively) and inhibits eotaxin-, eotaxin-2- and MCP-4-induced eosinophil chemotaxis with similar potencies.
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| BCC6057 | Teijin compound 1 |
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Potent chemokine CCR2b receptor antagonist (IC50 = 180 nM). Potently inhibits cell chemotaxis induced by MCP-1 (EC50 = 24 nM).
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| BCC6058 | G-15 |
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High affinity and selective GPER receptor antagonist (K<sub>i</sub> = 20 nM) that displays no affinity for ER<span class='symbol'>α</span> and ER<span class='symbol'>β</span> at concentrations up to 10 <span class='symbol'>μ</span>M. Inhibits agonist-induced calcium mobilization <em>in vitro</em> (EC<sub>50</sub> of ~185 nM) and antagonizes the antidepressive and renoprotective effects of estrogen <em>in vivo</em>.
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