Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1601 - 1608 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6002 | YM 511 |
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Orally active, potent aromatase (CYP19) inhibitor (IC<sub>50</sub> values are 0.4 and 0.12 nM at rat ovary and human placenta cells respectively) that only weakly inhibits the synthesis of other steroid hormones. Reduces plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth <em>in vitro</em> (IC<sub>50</sub> = 0.13 nM).
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| BCC6003 | NAD 299 hydrochloride |
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Selective, high affinity 5-HT<sub>1A</sub> receptor antagonist (K<sub>i</sub> = 0.6 nM <em>in vitro</em>). Enhances the action of selective 5-HT reuptake inhibitors and reverses citalopram-induced inhibition of serotonergic cell firing.
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| BCC6004 | AR-C 66096 tetrasodium salt |
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Potent and selective P2Y<sub>12</sub> receptor antagonist. Blocks ADP-induced inhibition of adenylyl cyclase <em>in vitro</em> (pK<sub>B</sub> =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC<sub>50</sub> = 8.16).
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| BCC6005 | AZ 10606120 dihydrochloride |
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Potent P2X<sub>7</sub> receptor antagonist (K<sub>D</sub> values are 1.4 and 19 nM at human and rat P2X<sub>7</sub> receptors respectively). Binds in a positive cooperative manner to sites distinct from, but coupled to, the ATP binding site and acts as a negative allosteric modulator. Inhibits tumor growth and displays antiangiogenic effects in mice.
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| BCC6006 | CART (55-102) (rat) |
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Cocaine- and amphetamine-regulated transcript (CART) with potent appetite-suppressing activity. Satiety factor; inhibits normal and starvation-induced feeding. Closely related to the actions of leptin and neuropeptide Y; blocks the neuropeptide Y-induced feeding response. Induces anxiety and stress behavior in rodents.
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| BCC6007 | CART (55-102) (human) |
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Cocaine- and amphetamine-regulated transcript (CART) with potent appetite-suppressing activity. Satiety factor; inhibits normal and starvation-induced feeding. Closely related to the actions of leptin and neuropeptide Y; blocks the neuropeptide Y-induced feeding response.
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| BCC6008 | CART (62-76) (rat, human) |
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Cocaine- and amphetamine-regulated transcript (CART) peptide fragment that inhibits food intake. Attenuates NPY-induced feeding and decreases food intake in food-restricted goldfish, and induces anxiogenic-like effects in elevated plus-maze test in rats. Modulates the activity of striatal noradrenergic, and corticostrial and hypothalamic serotoninergic systems, with no major effect on dopaminergic pathways in rat brain.
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| BCC6009 | PF 429242 |
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Reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC<sub>50</sub> = 0.175 <span class='symbol'>μ</span>M). Selective for site 1 protease against a panel of serine proteases. Inhibits rate of cholesterol synthesis in CHO cells (IC<sub>50</sub> = 0.53 <span class='symbol'>μ</span>M). Also displays antiviral activity. Cell permeable.
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