Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1617 - 1624 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6019 | SHU 9119 |
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Potent melanocortin MC<sub>3</sub> and MC<sub>4</sub> receptor antagonist (IC<sub>50</sub> values are 0.23 and 0.06 nM respectively) and MC<sub>5</sub> partial agonist (EC<sub>50</sub> = 0.12 nM). Upregulates expression of genes promoting lipogenesis and triglyceride storage (SCD1, LPL, ACC<span class='symbol'>α</span> and FAS), increases triglyceride synthesis and promotes insulin resistance. Increases food intake, body weight and fat mass when administered centrally <em>in vivo</em>.
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| BCC6020 | [D-Phe12,Leu14]-Bombesin |
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Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC<sub>50</sub> value of 2 <span class='symbol'>μ</span>M. Inhibits amylase release <em>in vitro</em> (IC<sub>50</sub> = 4 <span class='symbol'>μ</span>M) and attenuates bombesin-mediated suppression of food intake <em>in vivo</em>.
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| BCC6021 | γ1-MSH |
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Endogenous melanocortin MC<sub>3</sub> receptor agonist (pK<sub>i</sub> = 7.46) that displays ~ 40-fold selectivity over MC<sub>4</sub>. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and short-term analgesic activity <em>in vivo</em>.
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| BCC6022 | JKC 363 |
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Potent and selective melanocortin MC<sub>4</sub> receptor antagonist (IC<sub>50</sub> values are 0.5 and 44.9 nM at MC<sub>4</sub> and MC<sub>3</sub> respectively) that antagonizes the effects of <span class='symbol'>α</span>-MSH. Suppresses thyrotropin-releasing hormone (TRH) release, attenuates food intake and reduces formalin-induced pain <em>in vivo</em>.
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| BCC6023 | 4-IPP |
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Inhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity <em>in vivo</em>. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines <em>in vitro</em>.
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| BCC6024 | [Ala17]-MCH |
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Potent melanin-concentrating hormone (MCH) receptor agonist (EC50 values are 17 and 54 nM at MCH1 and MCH2 receptors respectively). Displays some selectivity towards MCH1 over MCH2 (Ki values are 0.16 and 34 nM respectively).
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| BCC6025 | MCL 0020 |
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Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.
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| BCC6026 | SID 7969543 |
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Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC<sub>50</sub> values are 0.76, >33 and >33 <span class='symbol'>μ</span>M at SF-1, ROR<span class='symbol'>α</span> and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells <em>in vitro</em> (IC<sub>50</sub> = 30 nM).
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