Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1625 - 1632 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6027 | Prion Protein 106-126 (human) |
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Prion peptide fragment that shares many physiochemical features with PrP<sup>Sc</sup>. Exhibits neurotoxicity caused by amplification of PrP<sup>C</sup>-associated signaling responses and induces NF-<span class='symbol'>κ</span>B-mediated apoptosis in the mouse neuroblastoma cell line N2a. Forms <span class='symbol'>β</span>-sheet-rich, insoluble, protease-resistant fibrils and is used as a model to study prion diseases <em>in vitro</em>.
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| BCC6028 | ACTH (1-39) |
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Potent endogenous melanocortin receptor 2 (MC2) agonist (EC50 = 57 pM). Component of the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid production and release from the adrenal cortex. Induces insulin resistance, promotes a proinflammatory profile and stimulates UCP-1 in adipocytes in vitro.
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| BCC6029 | BX 471 |
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Potent, selective non-peptide CCR1 antagonist (K<sub>i</sub> = 1 nM for human CCR1). Exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP-<span class='symbol'>α</span>/CCL3-induced intracellular Ca<sup>2+</sup> mobilization. Orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy.
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| BCC6030 | Decanoyl-RVKR-CMK |
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Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.
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| BCC6031 | BMS 753 |
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RAR<span class='symbol'>α</span>-selective agonist (K<sub>i</sub> = 2 nM).
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| BCC6032 | N2-Methyl-L-arginine |
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Selective L-arginine uptake inhibitor (K<sub>i</sub> = 500 <span class='symbol'>μ</span>M). Inhibits uptake of arginine by the lysosomal system c in human fibroblast <em>in vitro</em>.
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| BCC6033 | C-type natriuretic peptide (1-22) (human, rat, swine) |
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Endogenous peptide found in plasma and cerebrospinal fluid. Behaves as an agonist at natriuretic peptide receptor NPR2 (NPRB) and exhibits affinity for NPR3 (NPRC). Inhibits L-type calcium currents in myocytes and exhibits antiproliferative effects in cardiac fibroblasts in vitro. Regulates cartilage homeostasis, body fluid volume and exhibits vasodilatory activity in vivo.
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| BCC6034 | Brain natriuretic peptide (1-32) (human) |
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Endogenous peptide secreted from cardiac ventricles in response to volume increase and pressure overload that acts as an agonist at atrial natriuretic peptide (ANP) receptor A (NRP1). Decreases de novo collagen synthesis and increases MMP gene expression in vitro. Exhibits natriuretic, vasodilatory and lusitropic activity and inhibits the sympathetic and renin-angiotensin-aldosterone systems in vivo.
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