Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN3323 | Deacetylasperulosidic acid |
| 1. Deacetylasperulosidic acid may increase catalase activity. 2. Deacetylasperulosidic acid inhibits the reduction of ear swelling, and also cancels the suppression of IL-2 production along with the activation of natural killer cells in the same manner as that of Noni-ext. | |
| BCN1427 | Deacetylasperulosidic acid methyl ester |
| Ddeacetylasperulosidic acid methyl ester can lower the blood glucose level in normal mice. | |
| BCN3326 | 5-Methoxycanthin-6-one |
| 1. 5-Methoxycanthin-6-one exhibits a clear suppressive effect on the phagocytosis response upon activation with serum-opsonized zymosan in the range of IC₅₀ = 0.9-2.0 uM versus ibuprofen with IC₅₀ = 12.1 uM. 2. 5-Methoxycanthin-6-one displays moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC₅₀ values ranging from 13.5-15.4 uM versus doxorubicine with IC₅₀ = 1.5 uM. | |
| BCN3327 | Didymin |
| Didymin is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture, it induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Didymin possesses antioxidant, anti-inflammation and anti-cancer properties. | |
| BCN3328 | Notoginsenoside R2 |
| 1. Notoginsenoside R2 has neuroprotection against 6-OHDA-induced neurotoxicity, is associated with Notoginsenoside R2-mediated P90RSK and Nrf2 activation through MEK1/2-ERK1/2 pathways. | |
| BCN3330 | Trametenolic acid |
| 1. Trametenolic acid is a cytotoxic agent. 2. Trametenolic acid and Betulin as a new candidate of potent tyrosinase inhibitors, can decrease tyrosinase activity and melanin content. 3. Trametenolic acid exhibits a mode of mixed inhibition with a K I of 0.9 μM, K IS of 0.5 μM, and an IC50 of 7.25 μM. | |
| BCN3331 | Inotodiol |
| 1. Inotodiol shows significant anti-tumor and anti-tumor promoting activities, including human cervical cancer. 2. Inotodiol inhibits cell proliferation through apoptosis induction by activating caspase-3. 3. Inotodiol can inhibit proliferation and induce the apoptosis of A549 cells, and its molecular mechanism may be associated with the up-regulating expression of p53 and bax proteins and down-regulating expression of Bcl-2 protein, which arrested A549 cells in S phase. | |
| BCN3332 | Lanosterol |
| 1. Lanosterol induces mild depolarization of mitochondria and promotes autophagy. 2. Lanosterol is indicative of altered Lanosterol metabolism during PD pathogenesis. 3. 10 μM Lanosterol during IVM in medium without serum and bases on recombinant human chorionic gonadotrophin has a positive effect on maturation of prepubertal ewe oocytes. | |
