Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1729 - 1736 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6133 | MRS 2957 triethylammonium salt |
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Potent P2Y6 agonist (EC50 = 12 nM). Displays 14- and 66-fold selectivity against P2Y2 and P2Y4 receptors respectively.
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| BCC6134 | MRS 4062 triethylammonium salt |
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Selective P2Y4 receptor agonist (EC50 values are 23, 640, and 740 nM for hP2Y4, hP2Y2 and hP2Y6 respectively).
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| BCC6135 | KH CB19 |
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Selective, potent inhibitor of CDC2-like kinase (CLK) 1 and 4 (IC50 = 20 nM for CLK1). Suppresses serine/arginine-rich protein phosphorylation by CLKs under proinflammatory conditions. Displays selectivity over a panel of 71 protein kinases. ATP-competitive.
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| BCC6136 | PF-3644022 |
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Potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM). Inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM); exhibits oral efficacy in acute and chronic inflammatory models.
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| BCC6137 | HBX 41108 |
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Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC<sub>50</sub> = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC<sub>50</sub> = 0.8 <span class='symbol'>μ</span>M). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.
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| BCC6138 | Poly(I:C) |
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Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells. Transfection into NIT-1 <span class='symbol'>β</span> cells induces <span class='symbol'>β</span>-cell apoptosis. Immunostimulant.
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| BCC6139 | JNJ 10397049 |
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Selective OX2 receptor antagonist (pIC50 = 7.4 for chimeric OX2 receptors; pKB values are 5.9 and 8.5 for OX1 and OX2 receptors respectively). Shows no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. Achieves high level of OX2 receptor occupancy in the rat brain; exhibits sleep-promoting effects in rats.
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| BCC6140 | A 784168 |
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Potent TRPV1 antagonist (IC50 = 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin). Displays no activity against a range of receptors, including TRPA1, GABA, opioid, and purinergic receptors.
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