Hot Natural Products & Bioactive Compounds

BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.

Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.

Hot Products from BioCrick

Showing 1777 - 1784 of 9359 hot products

BioCrick hot natural products and bioactive compounds
Catalog No. Product Name
BCC6181 ISX 9
Neurogenic agent. Mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro.
BCC6182 SEN 12333
<span class='symbol'>&#945;</span>7 nicotinic acetylcholine receptor (nAChR) agonist (EC<sub>50</sub> = 1.6 <span class='symbol'>&#956;</span>M, K<sub>i</sub> = 260 nM at rat <span class='symbol'>&#945;</span>7 nAChRs). Also displays functional antagonism at histamine H<sub>3</sub> receptors (IC<sub>50</sub> = 103 nM) and weak agonist activity at human ganglionic <span class='symbol'>&#945;</span>3 nAChRs (IC<sub>50</sub> = 8.5 <span class='symbol'>&#956;</span>M). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. Brain penetrant and orally bioavailable.
BCC6183 Mephedrone hydrochloride
Inhibits striatal dopamine uptake and hippocampal 5-HT uptake in synaptosomes (IC50 values are 467 and 558 nM respectively). Administration causes a decrease in dopamine and 5-HT transporter function. Synthetic CNS stimulant; brain penetrant.
BCC6184 Fatostatin A
Inhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC<sub>50</sub> = 0.1 <span class='symbol'>&#956;</span>M); reverses hyperglycemia in diabetic (<em>ob/ob</em>) mice. Cell permeable.
BCC6185 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl 3-(3-nitrophenyl)acrylate
Inhibitor of Kr&#252;ppel-like factor 5 (KLF5) transcription factor (IC<sub>50</sub> = 2.3 <span class='symbol'>&#956;</span>M). Selectively active against colon cancer cells in a panel of 60 different cancer cell lines.
BCC6186 Ceranib 1
Ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC<sub>50</sub> = 3.9 <span class='symbol'>&#956;</span>M). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells.
BCC6187 GGsTop
Selective, irreversible <span class='symbol'>&#947;</span>-glutamyl transpeptidase (GGT) inhibitor; displays no inhibitory effects on glutamine amidotransferases or asparagine synthetase. Suppresses oxidative stress by inhibiting GGT activation. Prevents ischemia/reperfusion-induced acute kidney injury in rats <em>in vivo</em>.
BCC6188 YE 120
GPR35 agonist (EC<sub>50</sub> = 32 nM in DMR assays). Also displays partial agonist activity in a &#946;-arrestin translocation assay (EC<sub>50</sub> = 10.2 <span class='symbol'>&#956;</span>M).