Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN3741 | Poricoic acid A(F) |
| 1. Poricoic acid A(F) shows anti-inflammatory activity. | |
| BCN3743 | (+)-Sophoranol |
| 1. (+)-Sophoranol exhibits antiviral activity against the Coxsackie virus B3. 2. (+)-Sophoranol shows potent anti-HBV activity with an inhibitory potency against HBsAg secretion and against HBeAg secretion. | |
| BCN3746 | Corynantheine |
| 1. Corynantheine shows pronounced activity against Leishmania major promastigotes (IC50 at the micromolar level) but no significant in vitro antiplasmodial activity (against chloroquinesensitive Plasmodium falciparum). | |
| BCN3747 | Dihydrocorynantheine |
| 1. Dihydrocorynantheine exhibits significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 μg/mL), it also shows weak inhibitory action on KCl-induced contraction. 2. Dihydrocorynantheine shows pronounced activity against Leishmania major promastigotes (IC50 at the micromolar level) but no significant in vitro antiplasmodial activity (against chloroquinesensitive Plasmodium falciparum). | |
| BCN3748 | (Z)-23-Coumaroylhederagenin |
| 1. (Z)-23-Coumaroylhederagenin shows significant cytotoxicity against two human tumor cell lines, namely, oral epidermoid carcinoma KB and colorectal carcinoma HT29, and the IC(50) value in the range 1.2-3.6 microM. | |
| BCN3753 | Mesembrenone |
| 1. Mesembrenone, sucrose and obtusalin, the extracts of Sceletium tortuosum show antimalarial activity with activity values ranging between 1.47 ug/ml and 7.32 ug/ml, well below the 10 ug/ml cut off value. | |
| BCN3755 | Nirtetralin |
| 1. Nirtetralin suppresses effectively both HBsAg and HBeAg expression. | |
| BCN3757 | Viniferin |
| 1. α-Viniferin has anti-oxidant and anticancer activities. 2. ɛ-Viniferin and vincristine can enhance the anti-tumor effects efficiently by inducing HepG2 cell apoptosis. 3. α-Viniferin strongly inhibits the activities of the two CYPs dose dependently. 4. α-Viniferin suppresses the expression of proinflammatory genes iNOS and COX-2 in the early stage of inflammation by inhibiting the Akt/PI3K-dependent NF-κB activation and inhibits the production of proinflammatory mediators NO and PGE2 in the late stage by stimulating Nrf2-mediated HO-1 signaling pathway in LPS-stimulated BV2 microglial cells. | |
