Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1817 - 1824 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6222 | YM 244769 |
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Inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX). Potently inhibits Na+-dependent 45Ca2+ uptake (IC50 values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+ and Ca2+ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.
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| BCC6223 | ACHP |
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I<span class='symbol'>κ</span>B kinase inhibitor (IC<sub>50</sub> values are 8.5 and 250 nM for IKK<span class='symbol'>β</span> and IKK<span class='symbol'>α</span> respectively). Selective for IKK<span class='symbol'>α</span> and IKK<span class='symbol'>β</span> over IKK3, Syk and MAPKKK4 (IC<sub>50</sub> values are > 20 <span class='symbol'>μ</span>M). Inhibits DNA binding activity of NF-<span class='symbol'>κ</span>B. Blocks NF-<span class='symbol'>κ</span>B pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis.
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| BCC6224 | A 412997 dihydrochloride |
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Selective agonist for the dopamine D4 receptor (Ki values are 7.9 and 12.1 nM for human D4 and rat D4 receptors). Displays no affinity (<1000 nM) for other dopamine receptors. Shows efficacy in rat models of ADHD and short-term memory.
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| BCC6225 | HI TOPK 032 |
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T-LAK-cell-originated protein kinase (TOPK) inhibitor; exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC<sub>50</sub> = 9.6 <span class='symbol'>μ</span>M).
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| BCC6226 | EMPA |
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Highly potent, selective OX2 receptor antagonist (IC50 values are 2.3 nM and 1900 nM for OX2 and OX1 respectively). Displays negligible or no inhibition of a panel of 80 receptors. Blocks orexin-B- and orexin-A-invoked calcium mobilization in hOX2-expressing CHO cells (IC50 values are 7.9 nM and 8.8 nM respectively); reverses orexin-B-induced hyperlocomotion in mice. Brain penetrant.
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| BCC6227 | TC-E 5005 |
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Potent and selective PDE10A inhibitor (IC50 values are 7.28, 239, 779, 919, 3100 and 3700 nM at PDE10A, 2A, 11A, 5A, 7B and 3A respectively and >5000 nM at PDE1B, 4A, 6, 8A and 9A). Reverses MK 801-induced hyperactivity in vivo.
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| BCC6228 | TC HSD 21 |
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Potent 17<span class='symbol'>β</span>-hydroxysteroid dehydrogenase type 3 (17<span class='symbol'>β</span>-HSD3) inhibitor (IC<sub>50</sub> values are 6 and 40 nM at human and mouse 17<span class='symbol'>β</span>-HSD3 respectively). Displays no activity at 17<span class='symbol'>β</span>-HSD1, 17<span class='symbol'>β</span>-HSD2, ER<span class='symbol'>α</span>, androgen receptors or glucocorticoid receptors.
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| BCC6229 | LDV FITC |
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Fluorescent ligand that binds to the <span class='symbol'>α</span><sub>4</sub><span class='symbol'>β</span><sub>1</sub> integrin (VLA-4) with high affinity (K<sub>d</sub> values are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn<sup>2+</sup> respectively). Used to detect VLA-4 affinity and conformational changes.
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