Hot Natural Products & Bioactive Compounds

BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.

Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.

Hot Products from BioCrick

Showing 1841 - 1848 of 9359 hot products

BioCrick hot natural products and bioactive compounds
Catalog No. Product Name
BCC6246 SC 79
Activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.
BCC6247 Pam2CSK4
Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-<span class='symbol'>&#945;</span> production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.
BCC6248 TT 232
Peptide agonist for sst1/sst4 somatostatin receptors. Somatostatin analog; inhibits tyrosine kinase activity in human colon tumor cell lines. Demonstrates an antiproliferative effect both in vitro and in vivo and induces apoptosis in a pancreatic tumor cell line. Does not inhibit growth hormone release or secretion.
BCC6249 BI 6015
Hepatocyte nuclear factor 4<span class='symbol'>&#945;</span> (HNF4<span class='symbol'>&#945;</span>) antagonist. Represses expression of known HNF4<span class='symbol'>&#945;</span> target genes. Decreases HNF4<span class='symbol'>&#945;</span> DNA binding. Exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma.
BCC6250 4-CMTB
Free fatty acid receptor FFA2 agonist (pEC50 = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).
BCC6251 JW 67
Inhibitor of canonical Wnt pathway signaling (IC<sub>50</sub> = 1.17 <span class='symbol'>&#956;</span>M); targets the <span class='symbol'>&#946;</span>-catenin destruction complex (GSK-3<span class='symbol'>&#946;</span>/AXIN/APC) to induce <span class='symbol'>&#946;</span>-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-<span class='symbol'>&#954;</span>B pathways. Blocks G<sub>1</sub>/S cell cycle progression in colorectal cancer (CRC) cell lines (GI<sub>50</sub> = 7.8 <span class='symbol'>&#956;</span>M).
BCC6252 ML 171
NADPH oxidase 1 (NOX1) inhibitor; blocks NOX1-dependent ROS generation (IC<sub>50</sub> = 0.25 <span class='symbol'>&#956;</span>M in a HEK293-NOX1 recombinant cell system). Selective for NOX1 over other NADPH oxidases (IC<sub>50</sub> values are &#62; 3 <span class='symbol'>&#956;</span>M). Inhibits SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.
BCC6253 KB SRC 4
Potent and selective c-Src inhibitor (K<sub>i</sub> = 44 nM); does not inhibit c-Abl at concentrations up to 125 <span class='symbol'>&#956;</span>M. Selective between Src family members (K<sub>d</sub> values are 86, 160, 240, 720, 3200, 4400, and >40,000 nM for c-Src, Lck, Fgr, Yes, Lyn, Hck and Fyn respectively). Significantly inhibits cell growth in 4T1 mammary carcinoma tumor cells.