Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN7945 | Viscosalactone B |
| 1. Viscosalactone B shows selective COX-2 enzyme inhibition. 2. Viscosalactone B shows antiproliferative activity on NCI-H460 (Lung), HCT-116 (Colon), SF-268 (Central Nervous System; CNS and MCF-7 (Breast) human tumor cell lines. | |
| BCN7948 | Cimilactone A |
| 1. Cimilactone A shows significant anticomplement activity (IC(50)= 28.6 microm）. | |
| BCN7950 | Cimicifugoside H1 |
| 1. Cimicifugoside H1 shows the protective function to cerebral neuron during cerebral ischemia. | |
| BCN7951 | Cimiside E |
| 1. Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect. 2. Cimiside E arrests cell cycle and induces cell apoptosis in gastric cancer cells, it may be an effective chemopreventive agent against cancer. | |
| BCN7952 | Methyl kulonate |
| 1. Methyl kulonate shows interesting antimycobacterial activity (with MIC value of 70 uM ). 2. Methyl kulonate exhibits potent cytotoxicities against HL60 cells with IC50 values in the range of 2.8-5.8 uM. 3. Methyl kulonate inhibits production of nitric oxide (NO) in mouse macrophage RAW 264.7 cells induced by lipopolysaccharide (LPS). | |
| BCN7953 | Kulactone |
| 1. Kulactone exhibits significant activity against Escherichia coli with minimum inhibitory concentration of 12.5 μg/mL, close to that of neomycin (6.25 μg/mL). 2. Kulactone inhibited (ED(50) 2.5-6.2 microg/mL) the P388 cancer cell line. | |
| BCN7954 | Kulinone |
| 1. Kulactone has cytotoxic effects, with IC₅₀ values of 5.6-21.2 ug/mL. 2. Kulactone inhibited (ED(50) 2.5-6.2 microg/mL) the P388 cancer cell line. | |
| BCN7955 | 2beta-Acetoxyferruginol |
| 1. 2beta-Acetoxyferruginol showed activity against multidrug and methicillin-resistant Staphylococcus aureus (MRSA) strains and with Propionibacterium acnes, the major bacterial cause of acne, and the minimum inhibitory concentration value against P. acnes was 4 ug/ml. | |
