Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1897 - 1904 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6302 | HJC 0350 |
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Selective Epac2 inhibitor (IC<sub>50</sub> = 0.3 <span class='symbol'>μ</span>M). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.
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| BCC6303 | 3-Nitropropionic acid |
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Irreversible mitochondrial respiratory complex II (succinate dehydrogenase) inhibitor; induces autophagy in SH-SY5Y cells. Recapitulates Huntington's disease-like pathology and symptoms in primate and rodent models.
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| BCC6304 | Carbetocin |
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Oxytocin analog. Long-acting; displays agonist properties.
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| BCC6305 | 8-pCPT-2-O-Me-cAMP-AM |
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Selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP.This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.
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| BCC6306 | ML 202 |
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Potent activator of pyruvate kinase M2 (PKM2) (IC50 = 73 nM). Exhibits little or no activity against the pyruvate kinase isozymes PKM1, PKL and PKR.
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| BCC6307 | NS 6180 |
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Potent K<sub>Ca</sub>3.1 channel blocker (IC<sub>50</sub> values are 9, 14 and 15 nM for rat, human and mouse erythrocyte K<sub>Ca</sub>3.1 channels respectively). Exhibits ~ 50% inhibition of K<sub>Ca</sub>1.1, K<sub>V</sub>1.3, and K<sub>V</sub>11.1 channels, noradrenaline and dopamine transporters, L-type Ca<sup>2+</sup> channels and melatonin receptors at a concentration of 10 <span class='symbol'>μ</span>M. Potently inhibits IL-2 and IFN-<span class='symbol'>γ</span> production in rat lymphocytes (IC<sub>50</sub> ~ 50 nM); reduces DBNS-induced experimental colitis in rats.
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| BCC6308 | ML 190 |
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Selective <span class='symbol'>κ</span> opioid receptor (KOP) antagonist (IC<sub>50</sub> = 120 nM in a <span class='symbol'>β</span>-arrestin assay); displays >267-fold selectivity over <span class='symbol'>μ</span> and <span class='symbol'>δ</span> opioid receptors.
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| BCC6309 | SR 1001 |
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Retinoic acid receptor-related orphan receptor (ROR) <span class='symbol'>α</span> and <span class='symbol'>γ</span> inverse agonist (K<sub>i</sub> values are 172 and 111 nM for ROR<span class='symbol'>α</span> and ROR<span class='symbol'>γ</span> respectively). Demonstrates no activity at ROR<span class='symbol'>β</span> or LXR. Suppresses T<sub>h</sub>17 cell differentiation and cytokine expression and reduces the severity of disease in an animal model of mulitple sclerosis.
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