Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC8161 | Cynaropicrin |
| 1. Cynaropicrin has anti-inflammatory effects, it may participate in the inflammatory response by inhibiting the production of inflammatory mediators and the proliferation of lymphocytes and its inhibitory effect is mediated through conjugation with sulphydryl groups of target protein(s). 2. Cynaropicrin possesses immunomodulatory effects on cytokine release, nitric oxide production and immunosuppressive effects. 3. Cynaropicrin may be a potential anticancer agent against some leukocyte cancer cells such as lymphoma or leukemia, through pro-apoptotic activity. 4. Cynaropicrin shows in vivo activity against Trypanosoma brucei. 5. Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging. | |
| BCN8548 | Rhein-8-glucoside |
| 1. Rhein-8-glucoside has low laxative activity. | |
| BCN8485 | Periplocymarin |
| 1. Periplocymarin, a cardiac glycoside, has potential anti-cancer activity. 2. Octreotide-conjugated periplocymarin demonstrates tumor selectivity and may be useful as a targeting agent to improve the safety profile of cardiac glycosides for cancer therapy. | |
| BCN8496 | Irisolidone |
| 1. Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 uM. 2. Irisolidone possesses high α-amylase inhibitory activity. 3. Irisolidone may attenuate ethanol-induced gastritis by inhibiting the infiltration of immune cells, particularly neutrophils, through the regulation of CXCL-4 or IL-8 secretion. 4. Irisolidone has anti-inflammatory activity, it may inhibit inflammatory reactions via NF-κB pathway. 5. Irisolidone shows inhibitory activity on nitric oxide production from lipopolysaccharide-activated primary rat microglia. 6. Irisolidone shows antiproliferative activity against amelanotic melanoma cells. 7. Irisolidone shows anti-platelet aggregation effects. 8. Irisolidone has potent hepatoprotective activity. 9. Irisolidone shows potent inhibitory activity against Helicobacter pylori. | |
| BCN3802 | Nerylacetate |
| Nerylacetate and 1,5-dienes geranyl acetate are catalyzed to the cis-2,5-bis(hydroxymethyl)tetrahydrofurans 3 and 4 by OsO4. | |
| BCC8290 | 7,8-Dihydroxy-4-Methylcoumarin |
| 1. 4-Methyldaphnetin is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions. 2. 4-Methyldaphnetin inhibits the proinflammatory 5-lipoxygenase enzyme at micromolar concentrations. | |
| BCC8284 | 5,7-Dihydroxy-4-Methylcoumarin |
| 1. 5,7-Dihydroxy-4-methylcoumarin inhibits human neutrophil oxidative metabolism and elastase activity. 2. 5,7-Dihydroxy-4-methylcoumarin has in vitro platelet antiaggregatory property. 3. 5,7-Dihydroxy-4-methylcoumarin shows inhibition of the cyclooxygenase pathway. | |
| BCN3803 | L-carnosine |
| L-carnosine is an antioxidant naturally found in skeletal muscle, brain tissue, and the heart that protects cells against oxidative stress.L-carnosine plays an important role in inhibiting neuronal cell apoptosis through STAT3 signaling pathway after acute cerebral ischemia. L-carnosine may accelerate pressure ulcer healing during 4 weeks. | |
