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Hot Products

Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.

Hot products from the professional high-purity natural products manufacturer

Cat.No.	Product Name
BCC9233	Ilexgenin A
1. Ilexgenin A has ability to regulate lipid profile and protect the liver against high fat diet (HFD) -induced impairment. 2. Ilexgenin A ameliorates hepatic insulin signaling and gluconeogenesis by regulating lipolysis in white adipose tissue (WAT). 3. Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib on hepatoma growth. 4. Ilexgenin A has anti-atherosclerotic activity, it shows reduction of atherosclerosis in apolipoprotein E deficient mice. 5. Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner, it is useful in the management of cardiovascular diseases in obesity. 6. Ilexgenin A could be regarded as a promising agent for the treatment of melanoma, it exerts anti-melanoma activity by arresting the cell cycle at G0/G1 and regulating IL-6 and TNF-α production.
BCN1433	Soyasapogenol A
1. Soyasapogenol A and soyasapogenol B concentrated extracts show a greater ability to inhibit proliferation of cultured Hep-G2 when compared to a total soyasaponin extract that did not contain any soyasapogenols. 2. Soyasapogenol A directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α, which consequently resulted in the prevention of liver damage in the concanavalin A-induced hepatitis model. 3. Soyasapogenol A shows estrogenic activities.
BCN3817	Glucoraphanin
1. Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver. 2. Glucoraphanin can ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice. 3. Glucoraphanin and Glucoerucin effectively act as antagonists for the aryl hydrocarbon receptor, and this may contribute to their established chemoprevention potency. 4. Glucoraphanin has antioxidant activity, it has important effects on the reversion of fatty liver.
BCN3818	L-Phenylalanine
L-Phenylalanine has antibacterial activity.
BCN8552	Ilexsaponin B2
1. Ilexsaponin B2 is a cyclic nucleotide phosphodiesterase (PDE) inhibitor, it is active against PDEI and PDE5A dose-dependently in vitro.
BCC8154	Cochliophilin A
1. Cochliophilin A, host-specific plant signal, triggers a dynamic polymerization/depolymerization of F-actin in pathogenic A. cochlioides zoospores during early events of plant-peronosporomycete interactions. 2. Cochliophilin A elicites attractant activity against the zoospores of the phytopathogenic Aphanomyces cochlioides.
BCN3819	Phenylacetaldehyde
Phenylacetaldehyde is a oviposition inhibitor for the Pink Bollworm, it can attract Moths to bladder flower and to blacklight traps. Phenylacetaldehyde and carbon monoxide as effective additives for the selective hydrogenation of cyclooctadienes to cyclooctene over palladium catalysts.
BCN1418	Soyasaponin II
1. Soyasaponin II has antiviral effects, it can inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1. 2. Soyasaponins II can inhibit the conversion of fibrinogen to fibrin, it also can promote activation of the fibrinolytic system in a plasminogen-containing fibrin plate. 3. Soyasaponin II has hepatoprotective actions towards immunologically induced liver injury on primary cultured rat hepatocytes. 4. Soyasaponins are a potential antitumor compound and the apoptosis induced by soyasaponins is a key antitumor mechanism.