Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1953 - 1960 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6358 | ICA 121431 |
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Potent and selective inhibitor of human Na<sub>V</sub>1.3 and Na<sub>V</sub>1.1 channels (IC<sub>50</sub> values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC<sub>50</sub> values are >10 <span class='symbol'>μ</span>M for human Na<sub>V</sub>1.5 and Na<sub>V</sub>1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.
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| BCC6359 | ANQ 11125 |
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Selective motilin receptor antagonist (pKd = 8.24). Exhibits no effect on acetylcholine, substance P or serotonin stimulated intestinal contraction.
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| BCC6360 | J 147 |
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Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons <em>in vitro</em> (EC<sub>50</sub> = 25 - 200 nM). Reduces soluble A<span class='symbol'>β</span>40 and A<span class='symbol'>β</span>42 levels and increases BDNF levels in the hippocampus <em>in vivo</em>. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.
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| BCC6361 | LDN 212320 |
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Increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells. Displays neuroprotective activity in vivo. Shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.
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| BCC6362 | L 012 sodium salt |
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Luminal-based chemiluminescent probe. Detects NAPDH oxidase-derived reactive oxygen and nitrogen species (ROS and RNS). Active in vitro and in vivo.
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| BCC6363 | PG 931 |
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Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory function in hemorrhage-shocked rats.
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| BCC6364 | OXA (17-33) |
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Potent and selective peptide orexin OX<sub>1</sub> receptor agonist (EC<sub>50</sub> values are 8.29 and 187 nM for OX<sub>1</sub> and OX<sub>2</sub> receptors respectively). Truncated form of orexin A.
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| BCC6365 | iMDK |
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Suppressor of endogenous midkine (MDK) expression. Inhibits PI 3-K signaling in H441 lung adenocarcinoma cells. Selectively attenuates growth of MDK-expressing cancer cells. Induces apoptosis in H441 cells and suppresses growth of H441 cell xenografts in mice.
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