Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN3801 | 5-Methyl-2-furaldehyde |
| 5-Methylfurfural is a naturally occurring substance, found in cigarette smoke condensate, licorice essential oil, stored dehydrated orange powder, baked potato flour, volatile compounds of roast beef, aroma concentrate of sponge cake. bread and in coffee, tea and cocoa. A flavoring agent. | |
| BCN8358 | (-)-Steviol |
| 1. Steviol, a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the proliferation of the human osteosarcoma U2OS cell line in a dose- and time-dependent manner. 4. Steviol can treat polycystic kidney disease, it slowed cyst growth, in part, by reducing AQP2 transcription, promoted proteasome, and lysosome-mediated AQP2 degradation. | |
| BCN8292 | 1-Kestose |
| 1. 1-Kestose shows significant anti-hydroxyl radical potential . 2. 1-Kestose can promote intestinal Lactobacillus number, and influence the microorganisms as well as the intestinal and systemic immune responses. | |
| BCC9238 | Marinobufagin |
| 1. Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure. 2. Marinobufagenin can induce proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5. 3. Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. 4. Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity. | |
| BCN8681 | Cafestol |
| 1. Cafestol has anticarcinogenic activity. 2. Cafestol acts as an agonist ligand for both FXR and PXR, and this may contribute to its impact on cholesterol homeostasis. 3. Cafestol has an anti-inflammatory property, it inhibits Cyclic-Strain-induced interleukin-8, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 production in vascular endothelial cells. 4. Cafestol has protective effects against the CCl(4)-induced hepatotoxicity, which possibly involve mechanisms related to its ability to block the CYP2E1-mediated CCl(4) bioactivation and free radical scavenging effects. 5. Cafestol is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. 6. Cafestol has a peripheral antinociceptive effect and suggest that this effect is mediated by the release of endogenous opioids. 7. Cafestol inhibits angiogenesis by affecting the angiogenic signaling pathway. 8. Cafestol has antidiabetic activity, it increases glucose-stimulated insulin secretion in vitro and increases glucose uptake in human skeletal muscle cells. 9. Cafestol has a weak inhibitory effect on osteoclastogenesis and promotes osteoblast differentiation. | |
| BCC8166 | Desacetylcinobufotalin |
| 1. Desacetylcinobufotalin has significant antitumor activity through induction apoptosis via mitochondria pathway. 2. Desacetylcinobufotalin shows potent cytotoxic activities against HL-60 cell lines. | |
| BCN8337 | Neodiosmin |
| 1. Neodiosmin has poor aqueous solubility but exerts a good debittering effect and is a strong antioxidant with potential applications in foods, beverages, and pharmaceutical preparations. | |
| BCN8660 | Bacopaside I |
| 1. Bacopaside I has neuroprotective functions. 2. Bacopaside I exhibits an obvious antidepressant-like effect in mouse model of CUMS-induced depression that was mediated, at least in part, by modulating HPA hyperactivity and activating BDNF signaling pathway. 3. Bacopaside I is a modulator of Aquaporin-1 channel. 4. Bacopaside I has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid. | |
