Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1905 - 1912 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6310 | SR 2211 |
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Selective inverse agonist of retinoic acid receptor-related orphan receptor <span class='symbol'>γ</span> (ROR<span class='symbol'>γ</span>) (K<sub>i</sub> = 105 nM; IC<sub>50</sub> ~320 nM). Exhibits weak activity at liver X receptor <span class='symbol'>α</span> (LXR<span class='symbol'>α</span>); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of ROR<span class='symbol'>α</span>.
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| BCC6311 | H2L 5765834 |
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Antagonist of the lysophosphatidic acid receptors LPA1, LPA5 and LPA3 (IC50 values are 94, 463 and 752 nM respectively). Exhibits no effect at LPA2 or LPA4 receptors.
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| BCC6312 | KML 29 |
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Highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC<sub>50</sub> values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC<sub>50</sub> > 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC<sub>50</sub> = 2.5 nM and >50 <span class='symbol'>μ</span>M for 2-AG and AEA respectively).
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| BCC6313 | Eact |
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TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC<sub>50</sub> = 3 <span class='symbol'>μ</span>M). Ca<sup>2+</sup>-independent. Displays no effect on CFTR Cl<sup>-</sup> or ENaC Na<sup>+</sup> conductance. Stimulates submucosal gland secretion in human bronchi.
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| BCC6314 | CaCCinh-A01 |
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Calcium-activated chloride channel (CaCC) inhibitor (IC<sub>50</sub> ~ 10 <span class='symbol'>μ</span>M). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC<sub>50</sub> = 2.1 <span class='symbol'>μ</span>M, in TMEM16A-expressing FRT cells).
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| BCC6315 | H2L5186303 |
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Potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 values are 8.9, 1230 and 27354 nM for LPA2, LPA3 and LPA1 receptors respectively, in a LPA-elicited calcium mobilization assay).
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| BCC6316 | TC-G 1001 |
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GPR35 agonist (pEC<sub>50</sub> values are 7.59 and 8.36 for <span class='symbol'>β</span>-arrestin and G<span class='symbol'>α</span><sub>q-i5</sub> Ca<sup>2+</sup> assays respectively). Displays 1000-fold greater potency at human GPR35 receptors relative to mouse and rat GPR35 orthologs in an IP1 accumulation assay. More potent than zaprinast.
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| BCC6317 | ML 281 |
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Inhibitor of the serine/threonine kinase STK33 (IC50 = 14 nM). Exhibits >700-fold selectivity for STK33 over the structurally related protein kinase A (PKA); also exhibits 550-fold selectivity over Aurora kinase B.
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