Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1889 - 1896 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6294 | APETx2 |
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Acid-sensing ion channel 3 (ASIC3) channel blocker (IC50 values are 63 and 175 nM for homomeric rat and human ASIC3 channels). Also inhibits NaV1.8 and NaV1.2 channels (IC50 values are 55 and 114 nM respectively). Demonstrates analgesic properties against acid-induced and inflammatory pain.
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| BCC6295 | TAT 14 |
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Nrf2 activator; inhibits Nrf2/Keap1 interaction. Induces upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1. Suppresses LPS-induced TNF-<span class='symbol'>α</span> expression in THP-1 cells.
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| BCC6296 | Methoxyresorufin |
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Fluorometric substrate of cytochrome P450; displays preferential metabolism by rodent cytochrome P4501A2 (CYP1A2).
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| BCC6297 | Pentoxyresorufin |
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Fluorometric cytochrome P450 substrate.
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| BCC6298 | Skp2 Inhibitor C1 |
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Inhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.
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| BCC6299 | PF 04418948 |
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Potent EP<sub>2</sub> receptor antagonist (IC<sub>50</sub> = 16 nM for human EP<sub>2</sub> receptors). Displays over 2000-fold selectivity for EP<sub>2</sub> receptors over EP<sub>1</sub>, EP<sub>3</sub>, EP<sub>4</sub>, DP<sub>1</sub> amd CRTH<sub>2</sub> receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 <span class='symbol'>μ</span>M. Inhibits PGE<sub>2</sub>-induced increases in intracellular cAMP; reverses PGE<sub>2</sub>-invoked relaxation of mouse trachea (IC<sub>50</sub> = 2.7 nM).
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| BCC6300 | PD 334581 |
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Inhibitor of MEK1. Analog of PD 184352.
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| BCC6301 | TC ASK 10 |
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Potent ASK1 inhibitor (IC<sub>50</sub> = 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC<sub>50</sub> = 0.51 <span class='symbol'>μ</span>M), MEKK1, TAK1, IKK<span class='symbol'>β</span>, ERK1, JNK1, p38<span class='symbol'>α</span>, GSK-3<span class='symbol'>β</span>, PKC<span class='symbol'>θ</span> and B-raf (IC<sub>50</sub> values are > 10 <span class='symbol'>μ</span>M). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable.
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