Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1929 - 1936 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6334 | Shz 1 |
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Activator of early cardiac genes (including Nkx2.5) in pluripotent stem cells. Induces phenotypic differentiation in human mobilized peripheral blood mononuclear cells. Enhances myocardial regenerative repair by stem cells in a rat myocardial cryoinjury model.
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| BCC6335 | AS 1892802 |
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Potent, ATP-competitive ROCK inhibitor (IC<sub>50</sub> values are 52, 57 and 122 nM for human ROCK2, rat ROCK2 and human ROCK1 respectively by ELISA); also inhibits PKAC-<span class='symbol'>α</span> and PRKX (IC<sub>50</sub> values are 200 and 325 nM respectively). Exhibits analgesic effects in rat models of inflammatory (AIA) and noninflammatory (MIA) arthritic pain. Orally bioavailable.
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| BCC6336 | Peroxy Orange 1 |
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Fluorescent probe for imaging hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>); cell permeable. Displays an orange intracellular fluorescence in response to H<sub>2</sub>O<sub>2</sub> signals produced in RAW 264.7 macrophages and A431 cells during immune response and growth factor stimulation, respectively. Excitation wavelength 543 nm, emission between 545 and 750 nm.
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| BCC6337 | CYM 50769 |
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Novel non-peptide antagonist of neuropeptide W/B receptor 1 (NPBWR1, GPR7) (IC<sub>50</sub> = 0.12 <span class='symbol'>μ</span>M).
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| BCC6338 | ICA 110381 |
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K<sub>V</sub>7.2/7.3 activator (EC<sub>50</sub> = 0.38 <span class='symbol'>μ</span>M). Decreases neuronal excitability in CA1 hippocampal neurons. Exhibits anticonvulsive properties in amygdala-kindled rats, a model for complex partial seizures.
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| BCC6339 | SA 4503 dihydrochloride |
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Selective <span class='symbol'>σ</span>1 receptor agonist (IC<sub>50</sub> = 17.4 nM). Exhibits selectivity for <span class='symbol'>σ</span>1 over <span class='symbol'>σ</span>2 receptors. Inhibits angiotensin II-induced cardiomyocyte hypertrophy <em>in vitro</em> and attenuates myocardial hypertrophy <em>in vivo</em>. Enhances brain plasticity and sensorimotor function in a rat model of experimental stroke.
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| BCC6340 | UAMC 00039 dihydrochloride |
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Potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC<sub>50</sub> = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC<sub>50</sub> values are 78.6, 142 and 165 <span class='symbol'>μ</span>M, respectively). Orally available.
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| BCC6341 | 4-[4-(3-Hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1,4-dihydropyrrolo[3,4-d]pyrazol-5-yl]benzoic acid |
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Selective GPR55 antagonist. Inhibits LPI-induced Ca<sup>2+</sup> signaling (IC<sub>50</sub> = 0.21 <span class='symbol'>μ</span>M in HEK-GPR55 cells), ERK1/2 phosphorylation and GPR55-mediated transcription factor activation. Displays weak inhibition of acetylcholinesterase, <span class='symbol'>μ</span>-opioid receptor, KCNH2 and hERG. Decreases LPI-induced GPR55 internalization. Reduces experimental intestinal inflammation in mice.
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