Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN8343 | Racanisodamine |
| 1. Anisodamine, an anticholinergic drug, has antishock effect, which is intimately linked to alpha7nAChR-dependent anti-inflammatory pathway. 2. Anisodamine, a vasoactive drug, can abate endogenous endotoxaemia subsequent to splanchnic vasoconstriction due to hypovolaemia. 3. Anisodamine causes the changes of structure and function in the transmembrane domain of the Ca(2+)-ATPase from sarcoplasmic reticulum. 4. Anisodamine demonstrates a direct cardiac depressive action at the myocyte level, which may be related to, at least in part, NO production and cholinoceptor antagonism. 5. Anisodamine inhibits shiga toxin type 2-mediated tumor necrosis factor-alpha production in vitro and in vivo. 6. Anisodamine alleviates inflammatory damage by significantly reducing the expressions of VEGF and ICAM-1, and shows significant protective effects in an animal model of infusion phlebitis. 7. Anisodamine protects the heart from ischemia/reperfusion (I/R) injury induced by cardiac arrest (CA) and resuscitation. | |
| BCC5312 | Bevirimat |
| 1. Bevirimat is a HIV-1 maturation inhibitor. | |
| BCN3809 | L-Glutamic acid |
| L-Glutamic acid is probably an excitatory transmitter of major significance in the mammalian central nervous system. L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands. | |
| BCN3810 | Arnidiol |
| 1. Arnidiol shows inhibitory effects against Epstein-Barr virus early antigen (EBV-EA) activation with potencies either comparable with or stronger than that of glycyrrhetic acid, a known natural anti-tumor-promoter; it also possesses a wide range of cytotoxicity against human cancer cell lines, with GI50 values (concentration that yields 50% growth) of mostly less than 6 microM. 2. Arnidiol, heliantriol B0, heliantriol C and arnidiol possess marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, the 50% inhibitory dose of these compounds with respect to TPA-inflammation (1 microgram) is 0.03-0.2 mg/ear, suggests that they have anti-inflammatory activity. | |
| BCN3811 | Parishin A |
| Parishin A has good neuroprotective effects against brain disorders. | |
| BCN3812 | Parishin B |
| Parishin B has good neuroprotective effects against brain disorders, it can prevent vascular dementia. | |
| BCN3813 | Parishin C |
| 1. Parishin C can prevent vascular dementia. 2. Parishin C has antipsychotic effects, requires activation of 5-HT(1A) receptors. | |
| BCC8366 | Vicine |
| 1. Vicine is important natural fungicide. 2. "High levels" of vicine or convicine or both might have shortened the birds' survival time by enhancing the neurotoxicity induced by "lower levels" of beta-cyanoalanine. | |
