Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC9222 | Decursinol angelate |
| 1. Decursinol angelate has anti-tumor activity. 2. Decursinol angelate inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway. 3. Decursinol angelate has protective effects against amyloid β-protein-induced oxidative stress in the PC12 cell line. 4. Decursinol angelate has anti-inflammatory effects, it suppresses invasion and inflammatory activation of cancer cells through modulation of PI3K/AKT, ERK and NF-kappaB, its anti-inflammatory activity may contribute to its anti-cancer activity. 5. Decursinol angelate has in vitro and in vivo antifungal activity against Magnaporthe oryzae, the causal agent of rice blast. 6. Decursinol angelate possesses not only the anti-oxidant, but also the hepatoprotective activities in rats. 7. Decursinol angelate improves wound healing by upregulating the expression of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors. | |
| BCC8353 | Pseudoginsenoside Rh2 |
| 1. Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathway. 2. (20Z) -Pseudoginsenoside Rh2 and (20E)-Pseudoginsenoside Rh2 have antioxidative activity. | |
| BCC9251 | Tenuifoliside B |
| 1. Tenuifoliside B is a target lactate dehydrogenase inhibitor. 2. Tenuifoliside B has cognitive improving and cerebral protective effects. it can inhibit potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment in mice. | |
| BCN3823 | Methyl gallate |
| Methyl Gallate is a plant polyphenol with antioxidant, anticancer, anti-bacterial, and anti-inflammatory activities.Methyl gallate is a potent and highly specific inhibitor of herpes simplex virus in vitro. Methyl gallate also has a dual cyclooxygenase-2/5-lipoxygenase inhibitory activity. Methyl gallate can inhibit the growth of oral pathogens and S. mutans biofilm formation, and may be used to prevent the formation of oral biofilms. | |
| BCN3824 | Tartaric acid |
| 1. Tartaric acid, oxalic acid and histamine are the well-recognized pain-inducing agents in the stinging hairs of U. thunbergiana. | |
| BCN3825 | 2,5-Dihydroxyacetophenone |
| 2,5-Dihydroxyacetophenone is an uncompetitive inhibitor of murine tyrosinase (K(I) 0.28mm), it strongly inhibits both melanogenesis and cellular tyrosinase activity, it possesses anti-inflammatoryanti-anxiety, and neuroprotective qualities. 2,5-Dihydroxyacetophenone treatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs, it also can potentiate the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells. | |
| BCN8299 | tenuifoliside C |
| 1. Tenuifoliside C is a target lactate dehydrogenase inhibitor. 2. Tenuifoliside C significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1. | |
| BCN8678 | Flemiphilippinin A |
| 1. Flemiphilippin A has antioxidant activity, it shows DPPH radical scavenging activity with effective half maximal concentration (EC50) of 18.36 ug/mL. 2. Flemiphilippinin A (5 ug/mL) exhibits some level of antitumor activity against human hepatocellular carcinoma cell (BEL-7402), human lung epithelial (A-549) and human ileocecal adenocarcinoma cell (HCT-8). | |
