Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1969 - 1976 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6419 | RQ-00203078 |
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Potent TRPM8 antagonist (IC<sub>50</sub> values are 5.3 and 8.3 nM for rat and human channels respectively). Exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. Reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion <em>in vitro</em>. Also attenuates icilin-induced wet dog shakes in rats. Orally active.
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| BCC6420 | Spautin-1 |
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Inhibitor of autophagy; inhibits USP10 and USP13 activity (IC<sub>50</sub> values are 0.6 and 0.7 <span class='symbol'>μ</span>M respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.
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| BCC6427 | Retigabine |
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KV7 (KCNQ) channel activator (EC50 values are 0.6 - 100 μM for KV7.1 - KV7.5). Anticonvulsant. Orally bioavailable.
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| BCC6431 | Rostafuroxin (PST 2238) |
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Na<sup>+</sup>/K<sup>+</sup> ATPase modulator. Normalizes renal Na<sup>+</sup>/K<sup>+</sup> ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypersensitive rats. Controls mania-like behaviors in <em>Myshkin</em> mice having a Na<sup>+</sup>/K<sup>+</sup> ATPase <span class='symbol'>α</span>3 subunit mutation.
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| BCC6432 | CARIPORIDE |
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Selective Na<sup>+</sup>/H<sup>+</sup> exchanger isoform 1 (NHE1) inhibitor (IC<sub>50</sub> values are 0.05, 3 and 1000 <span class='symbol'>μ</span>M for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis <em>in vitro</em>. Reduces cardiac arrhythmia <em>in vivo</em>. Also promotes apoptosis in cancer cells overexpressing NHE1. Orally active.
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| BCC6439 | Tiplaxtinin(PAI-039) |
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Plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC<sub>50</sub> = 2.7 <span class='symbol'>μ</span>M). Induces vascular smooth muscle cell apoptosis <em>in vitro</em> and reduces carotid artery neointimal formation in a rat vascular injury model. Promotes thrombolysis in rat and dog models of acute arterial thrombosis. Orally available.
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| BCC6465 | Nitrotetrazolium Blue chloride |
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NBT(Nitro BT;p-Nitrotetrazolium blue) is a substrate for dehydrogenases; is used with the alkaline phosphatase substrate 5-Bromo- 4-Chloro-3-Indolyl Phosphate (BCIP) in western blotting and immunohistological staining procedures.
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| BCC6476 | 7-Ethoxyresorufin |
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Fluorometric substrate of cytochrome P450.
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