Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1945 - 1952 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6350 | ProINDY |
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DYRK1A/B inhibitor; prodrug form of INDY. Cell permeable. Inhibits phosphorylation of tau protein and rescues repressed calcineurin/NFAT signaling. Recovers <em>Xenopus</em> embryos from head malformation induced by DYRK1A overexpression <em>in vivo</em>.
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| BCC6351 | GMQ hydrochloride |
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Selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a.
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| BCC6352 | 1,9-Dideoxyforskolin |
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Inactive analog of forskolin; does not activate adenylyl cyclase.
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| BCC6353 | PAOPA |
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Allosteric modulator of dopamine D2 receptors. Prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized animal model of schizophrenia.
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| BCC6354 | PRT 4165 |
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Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1); inhibits self-ubiquitination (IC<sub>50</sub> = 3.9 <span class='symbol'>μ</span>M) but does not increase cellular levels of either subunit. Prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2<span class='symbol'>α</span> (Top2<span class='symbol'>α</span>). Also shown to inhibit the <em>in vitro</em> E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex, inhibiting H2A/H2AX ubiquitination. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination <em>in vitro</em> and <em>in vivo</em>.
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| BCC6355 | TC-E 5001 |
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Dual tankyrase (TNKS) inhibitor (K<sub>d</sub> values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC<sub>50</sub> = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC<sub>50</sub> >19 <span class='symbol'>μ</span>M). Inhibits Wnt signaling and stabilizes Axin2 levels.
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| BCC6356 | Qc 1 |
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Reversible, non-competitive inhibitor of threonine dehydrogenase (TDH) (IC50 ~500 nM). Induces autophagy and inhibits cell proliferation in mouse embryonic stem (ES) cells.
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| BCC6357 | Cyclotraxin B |
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Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.
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