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Hot Products

Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.

Hot products from the professional high-purity natural products manufacturer

Cat.No.	Product Name
BCN8689	Conicasterol
1. Conicasterol displays marked cytotoxic activity against human breast adenocarcinoma cell line (MCF-7) with the IC50 value of 6.23 ug/mL.
BCN8596	Dehydronuciferine
1. Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
BCN8691	Beta-Hydroxyisovalerylshikonin
1. Beta-Hydroxyisovalerylshikonin can significantly decrease viability of HCT116 cells (IC50 values of 30.9 ug/mL). 2. Beta-Hydroxyisovalerylshikonin has antiinflammatory and antitumor effects. 3. Beta-Hydroxyisovalerylshikonin has anti-adipogenic effect, it activated AMPK, which was followed by the downregulation of mature SREBP‑1c and fat-forming enzymes, leading to the inhibition of adipogenesis. 4. Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor cell lines.
BCN8313	Lycobetaine
1. Ungeremine is a potential biofungicide against Penicillium roqueforti and Aspergillus niger. 2. Ungeremine have strong antibacterial activity against Flavobacterium columnare . 3. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. 4. Ungeremine shows strong acetylcholinesterase inhibitory activity(IC(50) value of 0.35 microM). 5. Ungeremine has antiprotozoal activity, it shows good activity in in vitro assays against Trypanosoma brucei rhodesiense, T. cruzi.
BCC9006	Kahweol
1. Kahweol has anticarcinogenic activity. 2. Kahweol has anti-angiogenic activity. 3. Kahweol has anti-inflammatory activity, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity. 4. Kahweol has hepatoprotective and antioxidant effects on carbon tetrachloride-induced liver damage in mice.
BCN8443	(-)-Lotusine
1. Lotusine has antihypertension and antibacterial activities.
BCN8382	Gigantol
1. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. 2. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway. 3. Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. 4. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-κB signaling pathway. 5. Gigantol shows α-glucosidase inhibitory activity.
BCC8190	Isorhamnetin-3-O-galactoside
1. Isorhamnetin 3-O-galactoside shows antioxidant activity. 2. Isorhamnetin 3-O-galactoside has neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic for treatment of severe vascular inflammatory diseases. 3. Isorhamnetin 3-O-galactoside has potential anticoagulant activity, it possesses antithrombotic and profibrinolytic activity and offers bases for development of a novel anticoagulant. 4. Isorhamnetin 3-O-galactoside has anti-inflammatory activity against HMGB1-induced inflammatory responses in both HUVECs and CLP-induced septic mice. 5. Isorhamnetin 3-O-galactoside is a 5-lipoxygenase inhibitor, it may have therapeutic potential in skin inflammatory disorders in traditional medicine.