Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1873 - 1880 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6278 | ML 221 |
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Apelin receptor (APJ) antagonist (IC<sub>50</sub> values are 0.70 and 1.75 <span class='symbol'>μ</span>M in a cAMP assay and <span class='symbol'>β</span>-arrestin assay, respectively). Displays >37-fold selectivity over the closely related angiotensin II type 1 (AT<sub>1</sub>) receptor. Exhibits no toxicity towards human hepatocytes at concentrations >50 <span class='symbol'>μ</span>M.
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| BCC6279 | FSLLRY-NH2 |
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Selective PAR<sub>2</sub> peptide antagonist. Reverses taxol</a>-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
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| BCC6280 | SA 57 |
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Potent inhibitor of fatty acid amide hydrolase (FAAH) (IC<sub>50</sub> <10 nM). Also inhibits MAGL at higher concentrations (IC<sub>50</sub> values are 410 nM and 1.4 <span class='symbol'>μ</span>M respectively). Inhibits both human and mouse FAAH enzymes. Exhibits inhibitory activity against FAAH, MAGL and ABHD6 <em>in vivo</em>.
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| BCC6281 | Q94 hydrochloride |
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PAR<sub>1</sub> negative allosteric modulator (IC<sub>50</sub> = 916 nM); inhibits PAR<sub>1</sub>-G<span class='symbol'>α</span><sub>q</sub> interaction. Selective for PAR<sub>1</sub> over PAR<sub>2</sub>. Blocks thrombin-induced intracellular calcium mobilization (IC<sub>50</sub> = 10.3 nM), CCL2 expression, ERK1/2 and MLC phosphorylation, and IP<sub>3</sub> production in cells.
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| BCC6282 | COR 170 |
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Selective inverse agonist of CB2 receptors (Ki values are 3.8 and >10,000 nM for CB2 and CB1, respectively).
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| BCC6283 | G-36 |
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Antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ER<span class='symbol'>α</span>. Also inhibits estrogen-mediated calcium mobilization (IC<sub>50</sub> = 112 nM). Structural analog of G-1.
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| BCC6284 | SIB 1553A hydrochloride |
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Nicotinic acetylcholine receptor (nAChR) agonist. Displays selectivity for <span class='symbol'>β</span>4 subunit-containing receptors. Stimulates acetylcholine levels and other neurotransmitters relevant for cognitive processes. Improves attention deficits and memory performance in a Parkinson's disease model.
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| BCC6285 | VUF 10460 |
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Selective histamine H4 receptor agonist; displays 50-fold selectivity for the rat H4 receptor over the H3 subtype (pKi values are 5.75 and 7.46 for rat H3 and H4 receptors respectively). Also exhibits affinity for the human H4 receptor (pKi = 8.22).
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