Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1865 - 1872 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6270 | Huwentoxin IV |
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Selective Na<sub>V</sub>1.7 channel blocker. Preferentially inhibits neuronal Na<sub>V</sub>1.7, 1.2 and 1.3 (IC<sub>50</sub> values are 26, 150 and 338 nM respectively), compared to muscle subtypes Na<sub>V</sub>1.4 and 1.5 (IC<sub>50</sub> = >10 <span class='symbol'>μ</span>M). Inhibits the channel by binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration.
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| BCC6271 | Decynium 22 |
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Inhibitor of the plasma membrane monoamine transporter (PMAT) (K<sub>i</sub> = 0.10 <span class='symbol'>μ</span>M).
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| BCC6272 | ML 204 |
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Blocker of TRPC4 channels (IC<sub>50</sub> values are 0.96 and 2.6 <span class='symbol'>μ</span>M in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 <span class='symbol'>μ</span>M.
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| BCC6273 | WIN 18446 |
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Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC<sub>50</sub> = 0.3 <span class='symbol'>μ</span>M). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.
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| BCC6274 | Gue 1654 |
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Oxoeicosanoid receptor 1 (OXE-R) modulator. Selectively inhibits G<span class='symbol'>β</span><span class='symbol'>γ</span> but not G<span class='symbol'>α</span><sub>i</sub> signaling upon activation of the G<span class='symbol'>α</span><sub>i</sub>-<span class='symbol'>β</span><span class='symbol'>γ</span> heterotrimer by OXE-R. Inhibits G<span class='symbol'>β</span><span class='symbol'>γ</span>-mediated opening of GIRK1/2 channels in HEK293 cells.
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| BCC6275 | P11 |
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Potent antagonist of the integrin <span class='symbol'>α</span><sub>v</sub><span class='symbol'>β</span><sub>3</sub>-vitronectin interaction (IC<sub>50</sub> = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
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| BCC6276 | ML SA1 |
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Activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.
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| BCC6277 | TC-G 1006 |
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Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 35 nM), displays >100-fold selectivity against receptor subtypes S1P2-5. Induces a dose-dependent reduction in circulating blood lymphocyte counts in rodent models. Orally bioavailable.
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