Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN3794 | Thymol |
| Thymol is a positive allosteric modulator of human GABAA receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster, which has antioxidant, antimicrobial, anti-inflammatory, insecticidal and repellent properties. Thymol possesses anti-hepatotoxic activity, it prevents the CCl4-induced prolongation in pentobarbital sleeping time confirming hepatoprotectivity.Thymol has inhibitory effect on the release of human neutrophil elastase. | |
| BCN8448 | 9-Nitrocamptothecin |
| 1. Rubitecan is a novel oral inhibitor of topoisomerase I in the camptothecin class. 2. Rubitecan shows antitumour activity in patients with refractory pancreatic cancer who have failed prior treatments. | |
| BCN8478 | Rhodiosin; Herbacetin-7-O-glucorhamnoside |
| 1. Rhodiosin exhibits antioxidant activity. 2. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE). 3. Rhodiosin can inhibit cytochrome P450 2D6 non-competitively with the IC50 value of 0.761 microM. 4. Rhodiosin has hepatoprotective effects, it shows a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. 5. Rhodiosin shows noncompetitive inhibition against Flavobacterium prolyl endopeptidase, with an IC50 of 41 microM, the enzyme that plays a role in the metabolism of proline-containing neuropeptidase which is recognized to be involved in learning and memory. 6. Rhodiosin shows the inhibitory activity of lipase in isolated mouse plasma in vitro with the IC50 value of 0.133 mM, it can significantly suppress the elevation of the postprandial blood triglyceride level, suggests that it could used as the treatment of lifestyle-related diseases such as hyperlipidemia and exogeneous obesity and as health foods. | |
| BCN8590 | Aaptamine |
| 1. Aaptamine exerts an antiproliferative effect against NT2-R, a cisplatin-resistant subline of the human embryonal carcinoma cell line NT2. 2. Aaptamine activates p21 promoter in a p53-independent manner. 3. Aaptamine functions as a proteasome inhibitor. 4. Aaptamine is a competitive antagonist of alpha-adrenoceptors in vascular smooth muscles. 5. Aaptamine has potent cytotoxicity that may be explained by its ability to intercalate DNA. 6. Aaptamine shows anti-photoaging effect in UVB-irradiated human dermal fibroblasts and epidermal keratinocytes. 7. Aaptamine has anti-antiviral activity. | |
| BCN3795 | Faradiol |
| 1. Faradiol shows inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)- induced inflammation in mice; it can inhibit markedly the tumor-promoting effect of TPA (1 ug/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[α] anthracene (50 ug/mouse). 2. Faradiol shows inhibitory effects against Epstein-Barr virus early antigen (EBV-EA) activation with potencies either comparable with or stronger than that of glycyrrhetic acid, a known natural anti-tumor-promoter. | |
| BCN3796 | Chrysoeriol-7-O-glucoside |
| 1. Chrysoeriol-7-O-glucoside can strongly inhibit the classical pathway of the complement system. 2. Chrysoeriol-7-O-d-glucoside and luteolin-7-O-d-glucoside can inhibit palmitic acid uptake into small intestinal brush border membrane, apigenin-7-O-d-glucoside can inhibit alpha-amylase activity; they can enhance norepinephrine-induced lipolysis in fat cells. | |
| BCN8425 | Rosmanol |
| 1. Rosmanol has antioxidant activity, it can activate the antioxidant response element. 2. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and anxiolysis. 3. Rosmanol exhibits significant cytotoxicity towards the neuroblastoma cells. 4. Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. 5. Rosmanol has anti-inflammatory activity, it potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways. | |
| BCC8267 | Zeylenol |
| 1. (-)-Zeylenol shows antifeedant activity. 2. Zeylenol shows inhibitory activity toward the root growth of Lactuca sativa. 3. Zeylenol probably possesses anti-inflammatory activity by inhibiting the synthesis or release of various inflammatory mediators and might be used to induce human breast cancer MDA-MB231 cell apoptosis. | |
