Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1801 - 1808 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6206 | Y 11 |
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Potent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC<sub>50</sub> ~ 50 nM in an <em>in vitro</em> kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 <span class='symbol'>μ</span>M). Decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.
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| BCC6207 | ML 218 hydrochloride |
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Selective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, Kir6 (KATP) or KV11.1 (hERG) potassium channels. Orally active.
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| BCC6208 | S 32212 hydrochloride |
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Inverse agonist of 5-HT<sub>2C</sub> receptors (pK<sub>i</sub> = 8.18 at human 5-HT<sub>2C INI</sub> receptors). Also an antagonist of human <span class='symbol'>α</span><sub>2</sub>-adrenoceptors. Displays negligible affinity for <span class='symbol'>α</span><sub>1A</sub>-adrenoceptors, histamine H<sub>1</sub> receptors and muscarinic M<sub>1</sub> receptors.
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| BCC6209 | STF 083010 |
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Inhibitor of IRE1<span class='symbol'>α</span> endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138<sup>+</sup> multiple myeloma (MM) cells <em>in vitro</em>; inhibits bortezomib-induced XBP1 activity in myeloma xenografts <em>in vivo</em>. Does not alter IRE1<span class='symbol'>α</span> kinase activity.
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| BCC6210 | SHA 68 |
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Selective neuropeptide S receptor (NPSR) antagonist (IC50 values are 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively). Displays no activity against a range of 14 GPCRs, including vasopressin and oxytocin receptors.
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| BCC6211 | Kartogenin |
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Potently induces differentiation of human mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Reduces disease severity in a mouse model of osteoarthritis; displays protective effects against osteoarthritic stimuli in mature chondrocytes in vitro.
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| BCC6212 | NS 2028 |
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Potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).
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| BCC6213 | ML 213 |
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Selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay.
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