Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1721 - 1728 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6124 | KW 3902 |
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Selective adenosine A<sub>1</sub> receptor antagonist; displays 890-fold selectivity for rat A<sub>1</sub> receptors over A<sub>2A</sub> receptors (K<sub>i</sub> values are 0.19 and 170 nM respectively). Displays no effect on recombinant rat A<sub>3</sub> receptors expressed on CHO cells at concentrations up to 10 <span class='symbol'>μ</span>M. Exhibits diuretic and renal protective effects in rats.
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| BCC6126 | VU 591 hydrochloride |
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Selective renal outer medullary potassium channel (K<sub>ir</sub>1.1, ROMK) antagonist (IC<sub>50</sub> = 300 nM). Thought to block the intracellular pore of the K<sub>ir</sub>1.1 channel. Exhibits no effect on K<sub>ir</sub>7.1 at concentrations up to 10 <span class='symbol'>μ</span>M; does not inhibit K<sub>ir</sub>2.1, K<sub>ir</sub>2.3 or K<sub>ir</sub>4.1. Displays similar potency to VU 590 .
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| BCC6127 | MS 245 oxalate |
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High affinity 5-HT6 antagonist (Ki = 2.1 nM). Potentiates the hypolocomotor actions of (-)-nicotine in mice.
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| BCC6128 | PIR 3.5 |
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Negative control of IPA 3 a direct, non-competitive inhibitor of group I p21-activated kinase (Pak1).
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| BCC6129 | SB 297006 |
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Potent and selective CCR3 antagonist (IC<sub>50</sub> = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC<sub>50</sub> >27 <span class='symbol'>μ</span>M). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC<sub>50</sub> values are 80, 90 and 210 nM respectively).
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| BCC6130 | PF 184 |
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Potent and selective IKK<span class='symbol'>β</span> inhibitor (IC<sub>50</sub> = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1<span class='symbol'>β</span>-induced TNF-<span class='symbol'>α</span> production in a steroid-insensitive <em>in vitro</em> model of oxidative stress.
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| BCC6131 | SCH 529074 |
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Restores mutant p53 activity. Binds p53 DNA binding domain (K<sub>d</sub> = 1-2 <span class='symbol'>μ</span>M) and restores wild-type function to many oncogenic mutants by acting as a chaperone. Inhibits ubiquitination of p53 by HDM2. Triggers apoptosis in tumor cell lines and reduces tumor growth in a xenograft model.
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| BCC6132 | Kisspeptin 10 (rat) |
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Endogenous ligand for the rodent kisspeptin receptor (KISS1, GPR54). Rodent analog of the C-terminal KiSS-1 peptide, KiSS-1<sub>112-121</sub> (Kisspeptin 10).
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